Reduced progression of carotid intima media thickness by personalised pictorial presentation of subclinical atherosclerosis in VIPVIZA: A randomised controlled trial

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Reduced progression of carotid intima media thickness by personalised pictorial presentation of subclinical atherosclerosis in VIPVIZA : A randomised controlled trial

Nyman, Emma (author): Umeå universitet,Institutionen för folkhälsa och klinisk medicin

Grönlund, Christer (author): Umeå universitet,Institutionen för strålningsvetenskaper

Vanoli, Davide (author): Umeå universitet,Institutionen för folkhälsa och klinisk medicin

Liv, Per, 1979- (author): Umeå universitet,Institutionen för folkhälsa och klinisk medicin

Norberg, Margareta (author): Umeå universitet,Institutionen för folkhälsa och klinisk medicin

Bengtsson, Anna, 1973- (author): Umeå universitet,Institutionen för folkhälsa och klinisk medicin,Institutionen för epidemiologi och global hälsa

Wennberg, Patrik, 1972- (author): Umeå universitet,Institutionen för folkhälsa och klinisk medicin

Wester, Per, 1959- (author): Umeå universitet,Institutionen för folkhälsa och klinisk medicin

Näslund, Ulf (author): Umeå universitet,Institutionen för folkhälsa och klinisk medicin

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2023-01-27
2023
English.
In: Clinical Physiology and Functional Imaging. - : John Wiley & Sons. - 1475-0961 .- 1475-097X. ; 43:4, s. 232-241

Related links:: https://doi.org/10.1...; show more...; https://umu.diva-por... (primary) (Raw object); https://urn.kb.se/re...; https://doi.org/10.1...; show less...

Journal article (peer-reviewed)

Abstract Subject headings

Objectives: Reduced progression of atherosclerosis can decrease the risk of cardiovascular disease (CVD). This study aimed at evaluating the effect of a pictorial intervention showing atherosclerotic severity on the progression of carotid atherosclerosis.Methods: A prospective randomised open-label blinded end-point trial with participants aged 40–60 years enroled from a routine CVD prevention programme. The intervention group (n: 1575) and their treating physicians received an image based presentation of subclinical atherosclerotic severity measured by carotid ultrasound. The control group (n: 1579) did not receive any information about ultrasound results. Carotid ultrasound at baseline and at 3-year follow-up contained plaque detection and measurements of carotid intima media thickness (cIMT). The left, right and bilateral-mean-cIMT, plaque prevalence and total plaque area (TPA) at 3-year follow-up were compared between groups. Significance level was set to p = 0.01 to adjust for multiple comparisons.Results: The intervention group revealed reduced cIMT progression in the left-mean-cIMT of −0.011 mm (p = 0.001) compared with the control group. The intervention effect on cIMT progression was most prominent in individuals with increased cIMT and plaque prevalence at baseline (−0.021 mm, p = 0.005). There were no differences in progression between groups for the right-and bilateral-mean-cIMT (−0.005 mm, p = 0.223 and −0.005 mm, p = 0.036, respectively), nor any differences between groups for plaque prevalence or TPA (odds ratio 0.88, p = 0.09 and 0.89, p = 0.21, respectively).Conclusion: Pictorial presentation of subclinical atherosclerotic severity sent to both the individual and their treating physician resulted in significantly reduced left cIMT progression. Pictorial presentation has the potential to increase adherence in CVD prevention.

Subject headings

MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Kardiologi (hsv//swe)
MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cardiac and Cardiovascular Systems (hsv//eng)
MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Fysiologi (hsv//swe)
MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Physiology (hsv//eng)

Keyword

adherence
intervention
prevention
randomised controlled trial
ultrasound imaging

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By the author/editor: Nyman, Emma; Grönlund, Christ ...; Vanoli, Davide; Liv, Per, 1979-; Norberg, Margare ...; Bengtsson, Anna, ...; show more...; Wennberg, Patrik ...; Wester, Per, 195 ...; Näslund, Ulf; show less...

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MEDICAL AND HEALTH SCIENCES: MEDICAL AND HEAL ...; and Clinical Medicin ...; and Cardiac and Card ...

MEDICAL AND HEALTH SCIENCES: MEDICAL AND HEAL ...; and Basic Medicine; and Physiology

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By the university: Umeå University

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