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Hypervirulent R2029...
Hypervirulent R20291 Clostridioides difficile spores show disinfection resilience to sodium hypochlorite despite structural changes
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- Malyshev, Dmitry (författare)
- Umeå universitet,Institutionen för fysik
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- Jones, Imogen Anne (författare)
- Faculty of Health, University of Plymouth, Plymouth, UK
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- McKracken, Matthew (författare)
- Faculty of Health, University of Plymouth, Plymouth, UK
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- Öberg, Rasmus (författare)
- Umeå universitet,Institutionen för fysik
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- Harper, Glenn M. (författare)
- Faculty of Health, University of Plymouth, Plymouth, UK
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- Joshi, Lovleen Tina (författare)
- Faculty of Health, University of Plymouth, Plymouth, UK
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- Andersson, Magnus, 1975- (författare)
- Umeå universitet,Institutionen för fysik,Umeå Centre for Microbial Research (UCMR),The Biophysics and Biophotonics group
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(creator_code:org_t)
- 2023-03-06
- 2023
- Engelska.
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Ingår i: BMC Microbiology. - : BioMed Central (BMC). - 1471-2180. ; 23:1
- Relaterad länk:
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https://doi.org/10.1...
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https://umu.diva-por... (primary) (Raw object)
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
Ämnesord
Stäng
- Clostridioides difficile is a spore forming bacterial species and the major causative agent of nosocomial gastrointestinal infections. C. difficile spores are highly resilient to disinfection methods and to prevent infection, common cleaning protocols use sodium hypochlorite solutions to decontaminate hospital surfaces and equipment. However, there is a balance between minimising the use of harmful chemicals to the environment and patients as well as the need to eliminate spores, which can have varying resistance properties between strains. In this work, we employ TEM imaging and Raman spectroscopy to analyse changes in spore physiology in response to sodium hypochlorite. We characterize different C. difficile clinical isolates and assess the chemical’s impact on spores’ biochemical composition. Changes in the biochemical composition can, in turn, change spores’ vibrational spectroscopic fingerprints, which can impact the possibility of detecting spores in a hospital using Raman based methods.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Infektionsmedicin (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Infectious Medicine (hsv//eng)
- NATURVETENSKAP -- Fysik -- Annan fysik (hsv//swe)
- NATURAL SCIENCES -- Physical Sciences -- Other Physics Topics (hsv//eng)
- NATURVETENSKAP -- Biologi -- Mikrobiologi (hsv//swe)
- NATURAL SCIENCES -- Biological Sciences -- Microbiology (hsv//eng)
Nyckelord
- Bacterial spores
- C. difficile
- Laser tweezers Raman spectroscopy
- LTRS
- Raman spectroscopy
- Terbium
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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