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Single nucleotide p...
Single nucleotide polymorphism directed antiemetic treatment in women with breast cancer treated with neo- or adjuvant chemotherapy : a randomised multicentre phase II study. (EudraCT: 2015–000658-39)
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- Oliva, Delmy (author)
- Department of Oncology, Ryhov County Hospital, Jönköping, Sweden; delmy.oliva@rjl.se,Ryhov Cty Hosp, Sweden
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- Andersson, Bengt-Åke (author)
- Jönköping University,HHJ, Avdelningen för naturvetenskap och biomedicin,HHJ. Biomedicinsk plattform,Jonkoping Univ, Sweden
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- Shamoun, Levar (author)
- Department of Laboratory Medicine and Pathology, Region Jönköping County, Jönköping, Sweden,Reg Jonkoping Cty, Sweden
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- Lewin, Nongnit (author)
- Linköpings universitet,Centrum för social och affektiv neurovetenskap,Medicinska fakulteten
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- Nilsson, Mats P. (author)
- Linköpings universitet,Institutionen för hälsa, medicin och vård,Medicinska fakulteten,Reg Jonkoping Cty, Sweden
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- Schildt, Elsy-Britt (author)
- Department of Oncology, Kalmar County Hospital, Kalmar, Sweden,Kalmar Cty Hosp, Sweden
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- Fust, Lisa (author)
- Department of Oncology, Kalmar County Hospital, Kalmar, Sweden,Kalmar Cty Hosp, Sweden
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- Åsenlund, Ulrika (author)
- Trial Unit, Department of Oncology, Gävle County Hospital, Gävle, Sweden,Gavle Cty Hosp, Sweden
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- Sellerstam, Gunilla (author)
- Trial Unit, Department of Oncology, SöderHospital AB, Stockholm, Sweden
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- Elinder, Ellinor (author)
- Trial Unit, Department of Oncology, SöderHospital AB, Stockholm, Sweden
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- Sharp, Lena, PhD (author)
- Umeå universitet,Institutionen för omvårdnad,Department of Nursing, Umeå University, Umeå, Sweden; Regional Cancer Centre Stockholm-Gotland, Stockholm, Sweden,Umea Univ, Sweden; Reg Canc Ctr Stockholm Gotland, Sweden
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- Lewin, Freddi (author)
- Jönköping University,HHJ, Avdelningen för naturvetenskap och biomedicin,Department of Oncology, Ryhov County Hospital, Jönköping, Sweden,Ryhov Cty Hosp, Sweden; Jonkoping Univ, Sweden
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Department of Oncology, Ryhov County Hospital, Jönköping, Sweden; delmyoliva@rjl.se Ryhov Cty Hosp, Sweden (creator_code:org_t)
- International Institute of Anticancer Research, 2023
- 2023
- English.
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In: Anticancer Research. - : International Institute of Anticancer Research. - 0250-7005 .- 1791-7530. ; 43:6, s. 2671-2681
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Abstract
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- Background/aim: The role of single nucleotide polymorphisms (SNPs) in the frequency and intensity of chemotherapy-induced nausea and vomiting (CINV) in women with breast cancer (BC) is unclear. The primary purpose of this study was to compare/evaluate the effect of SNP-guided antiemetic treatment versus standard CINV treatment.Patients and methods: A randomised, factorial, phase II multicentre study design was used. Women planned for neoadjuvant or adjuvant chemotherapy with epirubicin, cyclophosphamide and fluorouracil (FEC /EC, with or without fluorouracil) for BC were randomised to SNP-guided antiemetic treatment (based on the results of SNP analyses) versus standard CINV treatment. Blood samples were taken before the treatment was initiated. Patient-reported data on CINV (during 10 days from onset of cancer treatment) and health-related quality of life (HRQoL), were collected before and after the first cancer treatment.Results: A total of 188 women were included. Overall, nausea was reported by 86% (n=129) of the patients during the ten-day period from the start of cancer treatment. The SNP genotype studied varied. In FAS-CD95, the genotypes AG and GG were overrepresented; in RB1-LPAR6, GG was overrepresented, and in CCL2, both AA and GG were overrepresented. We found no statistically significant difference in CINV between SNP-guided antiemetic treatment versus standard CINV treatment.Conclusion: SNP-guided antiemetic treatment could be as effective as standard treatment. SNP-guided antiemetic treatment of CINV is possibly useful in detecting patients with a higher or lower risk for CINV and thus may help in avoiding over-treatment with toxic components. CINV negatively affects the HRQL.Keywords: Breast cancer; chemotherapy-induced nausea and vomiting; single nucleotide polymorphism.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cancer and Oncology (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Hälsovetenskap -- Omvårdnad (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Health Sciences -- Nursing (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Gastroenterologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Gastroenterology and Hepatology (hsv//eng)
Keyword
- Breast cancer
- chemotherapy-induced nausea and vomiting
- single nucleotide polymorphism
Publication and Content Type
- ref (subject category)
- art (subject category)
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- By the author/editor
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Oliva, Delmy
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Andersson, Bengt ...
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Shamoun, Levar
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Lewin, Nongnit
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Nilsson, Mats P.
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Schildt, Elsy-Br ...
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show more...
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Fust, Lisa
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Åsenlund, Ulrika
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Sellerstam, Guni ...
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Elinder, Ellinor
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Sharp, Lena, PhD
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Lewin, Freddi
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show less...
- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Cancer and Oncol ...
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Health Sciences
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and Nursing
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Gastroenterology ...
- Articles in the publication
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Anticancer Resea ...
- By the university
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Umeå University
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Jönköping University
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Linköping University