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Whole genome sequen...
Whole genome sequence analysis and in-vitro probiotic characterization of Bacillus velezensis FCW2 MCC4686 from spontaneously fermented coconut water
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- Dhanya Raj, C.T. (författare)
- Department of Marine Science, Bharathidasan University, Tamilnadu, Tiruchirappalli, India
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- Suryavanshi, Mangesh V. (författare)
- Cardiovascular and Metabolic Sciences Department, Lerner Research Institute, Cleveland Clinic, OH, United States
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- Kandaswamy, Surabhi (författare)
- Manchester Centre for Genomic Medicine, School of Biological Sciences, Faculty of Biology Medicine and Health, The University of Manchester, 6th Floor, St Mary's Hospital, Oxford Road, Manchester, United Kingdom; School of Pharmacy and Biomedical Sciences, University of Central Lancashire, Preston, Lancashire, United Kingdom
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- Ramasamy, Kesava Priyan (författare)
- Umeå universitet,Institutionen för ekologi, miljö och geovetenskap,UMFpub
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- James, Rathinam Arthur (författare)
- Department of Marine Science, Bharathidasan University, Tamilnadu, Tiruchirappalli, India
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(creator_code:org_t)
- Elsevier, 2023
- 2023
- Engelska.
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Ingår i: Genomics. - : Elsevier. - 0888-7543 .- 1089-8646. ; 115:4
- Relaterad länk:
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https://doi.org/10.1...
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https://umu.diva-por... (primary) (Raw object)
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
Ämnesord
Stäng
- In this study, the probiotic potential of B. velezensis FCW2, isolated from naturally fermented coconut water, was investigated by in vitro and genomic characterization. Our findings highlight key features of the bacterium which includes, antibacterial activity, high adhesive potential, aggregation capacity, production of nutrient secondary metabolites. In vivo safety assessment revealed no adverse effects on zebrafish. WGS data of B. velezensis FCW2 revealed a complete circular genome of 4,147,426 nucleotides and a GC content of 45.87%. We have identified 4059 coding sequence (CDS) genes that encode proteins involved in stress resistance, adhesion and micronutrient production. The genes responsible for producing secondary metabolites, exopolysaccharides, and other beneficial nutrients were identified. The KEGG and COG databases revealed that genes mainly involved amino acid metabolism, carbohydrate utilization, vitamin and cofactor metabolism, and biological adhesion. These findings suggest that B. velezensis FCW2 could be a putative probiotic in the development of fermented foods.
Ämnesord
- NATURVETENSKAP -- Biologi -- Mikrobiologi (hsv//swe)
- NATURAL SCIENCES -- Biological Sciences -- Microbiology (hsv//eng)
Nyckelord
- Bacillus Velezensis
- FCW2
- Fermented coconut water
- Probiotic Bacteria
- Vitamin B12
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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