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Bioresorbable films...
Bioresorbable films of polycaprolactone blended with poly(lactic acid) or poly(lactic-co-glycolic acid)
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- Dodda, Jagan Mohan (författare)
- New Technologies – Research Centre (NTC), University of West Bohemia, Plzeň, Czech Republic
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- Azar, Mina Ghafouri (författare)
- New Technologies – Research Centre (NTC), University of West Bohemia, Plzeň, Czech Republic
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- Bělský, Petr (författare)
- New Technologies – Research Centre (NTC), University of West Bohemia, Plzeň, Czech Republic
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- Šlouf, Miroslav (författare)
- Institute of Macromolecular Chemistry CAS, Prague, Czech Republic
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- Gajdošová, Veronika (författare)
- Institute of Macromolecular Chemistry CAS, Prague, Czech Republic
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- Kasi, Phanindra Babu (författare)
- Department of Medical Chemistry and Biochemistry, Faculty of Medicine in Pilsen, Charles University, Plzeň, Czech Republic
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- Anerillas, Luis Oliveros (författare)
- Umeå universitet,Institutionen för integrativ medicinsk biologi (IMB)
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- Kovářík, Tomáš (författare)
- New Technologies – Research Centre (NTC), University of West Bohemia, Plzeň, Czech Republic
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(creator_code:org_t)
- Elsevier, 2023
- 2023
- Engelska.
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Ingår i: International Journal of Biological Macromolecules. - : Elsevier. - 0141-8130 .- 1879-0003. ; 248
- Relaterad länk:
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
Ämnesord
Stäng
- Recent complications on the use of polypropylene meshes for hernia repair has led to the development of meshes or films, which were based on resorbable polymers such as polycaprolactone (PCL), polylactic acid (PLA) and poly(lactic-co-glycolic acid) (PLGA). These materials are able to create suitable bioactive environment for the growth and development of cells. In this research, we mainly focused on the relations among structure, mechanical performance and biocompatiblity of PCL/PLA and PCL/PLGA and blends prepared by solution casting. The films were characterized regarding the chemical structure, morphology, physicochemical properties, cytotoxicity, biocompatibility and cell growth. All the films showed high tensile strength ranging from 9.5 to 11.8 MPa. SAXS showed that the lamellar stack structure typical for PCL was present even in the blend films while the morphological parameters of the stacks varied slightly with the content of PLGA or PLA in the blends. WAXS indicated preferential orientation of crystallites (and thus, also the lamellar stacks) in the blend films. In vitro studies revealed that PCL/PLGA films displayed better cell adhesion, spreading and proliferation than PCL/PLA and PCL films. Further the effect of blending on the degradation was investigated, to understand the significant variable within the process that could provide further control of cell adhesion. The results showed that the investigated blend films are promising materials for biomedical applications.
Ämnesord
- NATURVETENSKAP -- Kemi -- Polymerkemi (hsv//swe)
- NATURAL SCIENCES -- Chemical Sciences -- Polymer Chemistry (hsv//eng)
- TEKNIK OCH TEKNOLOGIER -- Kemiteknik -- Polymerteknologi (hsv//swe)
- ENGINEERING AND TECHNOLOGY -- Chemical Engineering -- Polymer Technologies (hsv//eng)
Nyckelord
- Biocompatibility
- Mechanical properties
- Nanoscale morphology
- Polycaprolactone
- Resorbable blends
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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