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Reproductive late e...
Reproductive late effects and testosterone replacement therapy in male childhood cancer survivors : a population-based study (the Fex-Can study)
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- Haavisto, Anu (författare)
- Karolinska Institutet,Department of Psychology and Logopedics, University of Helsinki, Helsinki, Finland; Department of Women's and Children's Health, Karolinska Institutet, Stockholm, Sweden; Faculty of Education and Welfare Studies, Åbo Akademi University, Turku, Finland,Univ Helsinki, Dept Psychol & Logoped, Helsinki, Finland.;Karolinska Inst, Dept Womens & Childrens Hlth, Stockholm, Sweden.;Abo Akad Univ, Fac Educ & Welf Studies, Turku, Finland.;Karolinska Inst, Dept Womens & Childrens Hlth, Visionsgatan 4, S-17164 Solna, Sweden.
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- Lampic, Claudia, 1964- (författare)
- Uppsala universitet,Karolinska Institutet,Umeå universitet,Institutionen för psykologi,Department of Women's and Children's Health, Karolinska Institutet, Stockholm, Sweden; Department of Public Health and Caring Sciences, Uppsala University, Uppsala, Sweden,Vårdvetenskap,Karolinska Inst, Dept Womens & Childrens Hlth, Stockholm, Sweden.;Umeå Univ, Dept Psychol, Umeå, Sweden. Turku Univ Hosp, Dept Pediat & Adolescent Med, Turku, Finland. Univ Turku, FICANWEST, Turku, Finland.
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- Wettergren, Lena (författare)
- Uppsala universitet,Karolinska Institutet,Department of Women's and Children's Health, Karolinska Institutet, Stockholm, Sweden; Department of Public Health and Caring Sciences, Uppsala University, Uppsala, Sweden,Vårdvetenskap,Karolinska Inst, Dept Womens & Childrens Hlth, Stockholm, Sweden.
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- Lähteenmäki, Päivi M. (författare)
- Department of Women's and Children's Health, Karolinska Institutet, Stockholm, Sweden; Department of Pediatric and Adolescent Medicine, Turku University Hospital, Turku, Finland; FICANWEST, University of Turku, Turku, Finland,Karolinska Inst, Dept Womens & Childrens Hlth, Stockholm, Sweden.
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- Jahnukainen, Kirsi (författare)
- Children's Hospital, University of Helsinki and Helsinki University Hospital, Helsinki, Finland; NORDFERTIL Research Lab Stockholm, Department of Women's and Children's Health, Karolinska Institutet, Stockholm, Sweden,Univ Helsinki, Helsinki Univ Hosp, Helsinki, Finland.;Helsinki Univ Hosp, Helsinki, Finland.;Karolinska Inst, Dept Womens & Childrens Hlth, NORDFERTIL Res Lab Stockholm, Stockholm, Sweden.
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(creator_code:org_t)
- John Wiley & Sons, 2024
- 2024
- Engelska.
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Ingår i: International Journal of Cancer. - : John Wiley & Sons. - 0020-7136 .- 1097-0215. ; 154:12, s. 2121-2131
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Abstract
Ämnesord
Stäng
- Childhood cancer survivors are at risk of various endocrine late effects affecting their quality of life. The aim of this study was to assess the prevalence and predictors of endocrine and reproductive outcomes in young adult survivors. A secondary aim was to assess possible associations between testosterone replacement therapy (TRT) and other endocrine, cardiovascular and psychosocial late effects. This nationwide study comprised 1212 male childhood cancer survivors aged 19–40 years, identified through the National Quality Registry for Childhood Cancer in Sweden. Median age at diagnosis during 1981–2017 was 7 (range 0–17) and at study 29 (19–40) years. The study combined self-report survey data with cancer treatment data from the national registry. Hormone-induced puberty was self-reported by 3.8% of the survivors and ongoing TRT by 6.0%. In separate logistic regression analyses, these treatments were associated with hematopoietic stem cell transplantation and cranial radiotherapy. Hormone-induced puberty was additionally associated with younger age at diagnosis. Men with TRT had a higher prevalence of other endocrine deficiencies, cholesterol medication, depressive symptoms and fatigue as well as a lower probability of living with a partner, having a biological child or current occupation. In the total male cohort, 28.2% reported having a biological child. Reassuring reproductive outcomes after less intensive therapies and low frequency of TRT were observed in young adult male childhood cancer survivors treated in the most recent treatment era. However, men with TRT suffered from several other endocrine, cardiovascular and psychosocial late effects, indicating a need for long-term monitoring of this high-risk group.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cancer and Oncology (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Endokrinologi och diabetes (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Endocrinology and Diabetes (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Reproduktionsmedicin och gynekologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Obstetrics, Gynaecology and Reproductive Medicine (hsv//eng)
Nyckelord
- childhood cancer survivors
- late effects
- registry study
- subfertility
- testosterone replacement therapy
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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