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Effects of contact ...
Effects of contact location and voltage amplitude on speech and movement in bilateral subthalamic nucleus deep brain stimulation.
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Tripoliti, Elina (author)
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Zrinzo, Ludvic (author)
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Martinez-Torres, Irene (author)
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Tisch, Stephen (author)
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Frost, Eleanor (author)
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Borrell, Ellie (author)
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- Hariz, Marwan I (author)
- Umeå universitet,Neurokirurgi
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Limousin, Patricia (author)
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(creator_code:org_t)
- 2008-09-11
- 2008
- English.
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In: Movement disorders : official journal of the Movement Disorder Society. - : Wiley. - 1531-8257. ; 23:16, s. 2377-83
- Related links:
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
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- Subthalamic nucleus deep brain stimulation (STN-DBS) is particularly effective in improving limb symptoms in Parkinson's disease. However, speech shows a variable response. Contact site and amplitude of stimulation have been suggested as possible factors influencing speech. In this double blind study, we assessed 14 patients post bilateral STN-DBS, without medication. Six conditions were studied in random order as follows: stimulation inside the STN at low voltage (2 V) and at high voltage (4 V); above the STN at 2 V and at 4 V, at usual clinical parameters, and off-stimulation. The site of stimulation was defined on the postoperative stereotactic MRI data. Speech protocol consisted of the assessment of intelligibility of the dysarthric speech, maximum sustained phonation, and a 1-minute monologue. Movement was assessed using the UPDRS-III. Stimulation at 4 V significantly reduced the speech intelligibility (P = 0.004) independently from the site of stimulation. Stimulation at 4 V significantly improved the motor function. Stimulation inside the nucleus was significantly more effective than outside the nucleus (P = 0.0006). The significant improvement in movement coupled with significant deterioration in speech intelligibility when patients are stimulated inside the nucleus at high voltage indicates a critical role for electrical stimulation parameters in speech motor control.
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- ref (subject category)
- art (subject category)
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