id:"swepub:oai:DiVA.org:umu-25669"
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| Fältnamn | Indikatorer | Metadata |
|---|---|---|
| 000 | 02971naa a2200325 4500 | |
| 001 | oai:DiVA.org:umu-25669 | |
| 003 | SwePub | |
| 008 | 090827s2010 | |||||||||||000 ||eng| | |
| 024 | 7 | a https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-256692 URI |
| 024 | 7 | a https://doi.org/10.3892/ijo_000007392 DOI |
| 040 | a (SwePub)umu | |
| 041 | a engb eng | |
| 042 | 9 SwePub | |
| 072 | 7 | a ref2 swepub-contenttype |
| 072 | 7 | a art2 swepub-publicationtype |
| 100 | 1 | a Wibom, Carl,d 1977-u Umeå universitet,Onkologi4 aut0 (Swepub:umu)caewim02 |
| 245 | 1 0 | a Vandetanib alters the protein pattern in malignant glioma and normal brain in the BT4C rat glioma model |
| 264 | 1 | b Spandidos Publications,c 2010 |
| 338 | a print2 rdacarrier | |
| 520 | a The treatment of glioblastoma is unsatisfactory. Improved understanding of the biological effects of treatment, together with development of new tools to predict outcome of the initiated treatment are therefore of great need. Vandetanib (ZD6474) is mainly a vascular endothelial growth factor (VEGF) and epidermal growth factor (EGF) receptor tyrosine kinase inhibitor. This study investigated the pattern of protein expression in brain tumor and normal brain tissue, following treatment with vandetanib in a rat glioma model. BT4C-cells were stereotactically implanted into the brain of BD IX rats. The rats were divided into three different experiments. The treatment schedule for experiments one and two consisted of daily, oral doses of vandetanib from day 6 until day 12 or 20 after implantation, respectively. In the third experiment, each animal received a single dose of vandetanib on day 19 after implantation and was then sacrificed 2, 8 or 24 h thereafter. The protein expression profiles were analyzed by SELDI-TOF-MS and evaluated with multivariate statistical methods. Following treatment with vandetanib, we found significantly altered protein expression pattern in malignant glioma and normal brain. Analyzing protein spectra is an interesting option to assess biological effects induced in brain tissue by signal transduction inhibitors such as vandetanib. | |
| 700 | 1 | a Sandström, Mariau Umeå universitet,Onkologi4 aut0 (Swepub:umu)maalin96 |
| 700 | 1 | a Henriksson, Rogeru Umeå universitet,Onkologi4 aut0 (Swepub:umu)rohe0003 |
| 700 | 1 | a Antti, Henriku Umeå universitet,Kemiska institutionen4 aut0 (Swepub:umu)hean0004 |
| 700 | 1 | a Johansson, Mikaelu Umeå universitet,Onkologi4 aut0 (Swepub:umu)mijo0025 |
| 700 | 1 | a Bergenheim, A Tommyu Umeå universitet,Neurokirurgi4 aut0 (Swepub:umu)tobe0004 |
| 710 | 2 | a Umeå universitetb Onkologi4 org |
| 773 | 0 | t International Journal of Cancerd : Spandidos Publicationsg 37:4, s. 879-890q 37:4<879-890x 0020-7136x 1097-0215x 1019-6439x 1791-2423 |
| 856 | 4 | u https://www.spandidos-publications.com/ijo/37/4/879/download |
| 856 | 4 8 | u https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-25669 |
| 856 | 4 8 | u https://doi.org/10.3892/ijo_00000739 |
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