Search: id:"swepub:oai:DiVA.org:umu-32172" >
Four major transcri...
Four major transcriptional responses in the methionine/threonine biosynthetic pathway of Saccharomyces cerevisiae
-
Mountain, Harry A (author)
-
- Byström, Anders S (author)
- Umeå universitet,Institutionen för molekylärbiologi (Teknisk-naturvetenskaplig fakultet)
-
Larsen, J T (author)
-
show more...
-
Korch, C (author)
-
show less...
-
(creator_code:org_t)
- John Wiley & Sons, 1991
- 1991
- English.
-
In: Yeast. - : John Wiley & Sons. - 0749-503X .- 1097-0061. ; 7:8, s. 781-803
- Related links:
-
https://urn.kb.se/re...
-
show more...
-
https://doi.org/10.1...
-
show less...
Abstract
Subject headings
Close
- Genes encoding enzymes in the threonine/methionine biosynthetic pathway were cloned and used to investigate their transcriptional response to signals known to affect gene expression on the basis of enzyme specific-activities. Four major responses were evident: strong repression by methionine of MET3, MET5 and MET14, as previously described for MET3, MET2 and MET25; weak repression by methionine of MET6; weak stimulation by methionine but no response to threonine was seen for THR1, HOM2 and HOM3; no response to any of the signals tested, for HOM6 and MES1. In a BOR3 mutant, THR1, HOM2 and HOM3 mRNA levels were increased slightly. The stimulation of transcription by methionine for HOM2, HOM3 and THR1 is mediated by the GCN4 gene product and hence these genes are under the general amino acid control. In addition to the strong repression by methionine, MET5 is also regulated by the general control.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Mikrobiologi inom det medicinska området (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Microbiology in the medical area (hsv//eng)
Keyword
- Methionine/threonine biosynthesis
- transcriptional regulation
- general amino acid control
- yeast
- Microbiology
- Mikrobiologi
Publication and Content Type
- ref (subject category)
- art (subject category)
Find in a library
-
Yeast
(Search for host publication in LIBRIS)
To the university's database