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Two automatic QT al...
Two automatic QT algorithms compared with manual measurement in identification of long QT syndrome
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- Diamant, Ulla-Britt (author)
- Umeå universitet,Institutionen för kirurgisk och perioperativ vetenskap,Pediatrik
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- Winbo, Annika (author)
- Umeå universitet,Pediatrik
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- Stattin, Eva-Lena (author)
- Umeå universitet,Medicinsk och klinisk genetik
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- Rydberg, Annika (author)
- Umeå universitet,Pediatrik
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- Kesek, Milos (author)
- Umeå universitet,Medicin
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- Jensen, Steen M (author)
- Umeå universitet,Medicin
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(creator_code:org_t)
- Elsevier BV, 2010
- 2010
- English.
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In: Journal of Electrocardiology. - : Elsevier BV. - 0022-0736 .- 1532-8430. ; 43:1, s. 25-30
- Related links:
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
Subject headings
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- BACKGROUND: Long QT syndrome (LQTS) is an inherited disorder that increases the risk of syncope and malignant ventricular arrhythmias, which may result in sudden death.METHODS: We compared manual measurement by 4 observers (QT(manual)) and 3 computerized measurements for QT interval accuracy in the diagnosis of LQTS: 1. QT measured from the vector magnitude calculated from the 3 averaged orthogonal leads X, Y, and Z (QTVCG) and classified using the same predefined QTc cut-points for classification of QT prolongation as in manual measurements; 2. QT measured by a 12-lead electrocardiogram (ECG) program (QTECG) and subsequently classified using the same cut-points as in (1) above; 3. The same QT value as in (2) above, automatically classified by a 12-lead ECG program with thresholds for QT prolongation adjusted for age and sex (QTinterpret). The population consisted of 94 genetically confirmed carriers of KCNQ1 (LQT1) and KCNH2 (LQT2) mutations and a combined control group of 28 genetically confirmed noncarriers and 66 unrelated healthy volunteers.RESULTS: QT(VCG) provided the best combination of sensitivity (89%) and specificity (90%) in diagnosing LQTS, with 0.948 as the area under the receiver operating characteristic curve. The evaluation of QT measurement by the 4 observers revealed a high interreader variability, and only 1 of 4 observers showed acceptable level of agreement in LQTS mutation carrier identification (kappa coefficient >0.75).CONCLUSION: Automatic QT measurement by the Mida1000/CoroNet system (Ortivus AB, Danderyd, Sweden) is an accurate, efficient, and easily applied method for initial screening for LQTS.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Kardiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cardiac and Cardiovascular Systems (hsv//eng)
Keyword
- Long QT syndrome
- QT interval
- Automatic measurement
- Vectorcardiography
- Mutation analysis
- MEDICINE
- MEDICIN
Publication and Content Type
- ref (subject category)
- art (subject category)
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