id:"swepub:oai:DiVA.org:umu-39542"
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| Fältnamn | Indikatorer | Metadata |
|---|---|---|
| 000 | 03981naa a2200409 4500 | |
| 001 | oai:DiVA.org:umu-39542 | |
| 003 | SwePub | |
| 008 | 110131s2011 | |||||||||||000 ||eng| | |
| 009 | oai:prod.swepub.kib.ki.se:122656720 | |
| 024 | 7 | a https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-395422 URI |
| 024 | 7 | a https://doi.org/10.1159/0003187432 DOI |
| 024 | 7 | a http://kipublications.ki.se/Default.aspx?queryparsed=id:1226567202 URI |
| 040 | a (SwePub)umud (SwePub)ki | |
| 041 | a engb eng | |
| 042 | 9 SwePub | |
| 072 | 7 | a ref2 swepub-contenttype |
| 072 | 7 | a art2 swepub-publicationtype |
| 100 | 1 | a Österlund, Camilla,d 1978-u Umeå universitet,Lungmedicin4 aut0 (Swepub:umu)caaosd97 |
| 245 | 1 0 | a Non-proteolytic aeroallergens from mites, cat and dog exert adjuvant-like activation of bronchial epithelial cells |
| 264 | c 2010-12-22 | |
| 264 | 1 | b S. Karger AG,c 2011 |
| 338 | a print2 rdacarrier | |
| 520 | a Background: Exposure to seasonal or indoor allergens may cause sensitisation and development of allergic airway diseases. We have previously demonstrated that the non-proteolytic major house dust mite (HDM) allergen Der p 2 stimulates pro-inflammatory responses in bronchial epithelial cells. We aimed to determine if other clinically relevant non-proteolytic aeroallergens originating from HDMs, storage mites, cat, dog, birch and timothy also activate respiratory epithelial cells. Methods: Cultures of human bronchial epithelial cell line BEAS-2B, normal human bronchial epithelial cells and alveolar epithelial cell line A549 were exposed to recombinant (r)Der p 2, natural (n)Der f 2, rEur m 2, rLep d 2, rFel d 1, nFel d 1, rCan f 2, rBet v 1 or rPhl p 5a. A panel of secreted mediators and expression of cell adhesion receptors involved in recruitment, survival and adhesion of inflammatory cells in asthmatic airways was assessed. Results: The mite allergens rDer p 2, nDer f 2, rEur m 2 and rLep d 2 as well as the cat and dog allergens rFel d 1, nFel d 1 and rCan f 2 induced granulocyte colony-stimulating factor, granulocyte-macrophage colony-stimulating factor, interleukin (IL)-6, IL-8, monocyte-chemotactic protein-1 and macrophage inflammatory protein-3α secretion from bronchial epithelial cells as well as surface expression of intracellular adhesion molecule-1. The pollen allergens rBet v 1 and rPhl p 5a from birch and timothy did not activate the cells. None of the studied allergens affected the alveolar epithelial cells. Conclusion: These results show that both mite and structurally unrelated cat and dog allergens can activate respiratory epithelial cells by adjuvant-like protease-independent mechanisms. | |
| 650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Lungmedicin och allergi0 (SwePub)302192 hsv//swe |
| 650 | 7 | a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Respiratory Medicine and Allergy0 (SwePub)302192 hsv//eng |
| 650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Medicinska och farmaceutiska grundvetenskaperx Immunologi inom det medicinska området0 (SwePub)301102 hsv//swe |
| 650 | 7 | a MEDICAL AND HEALTH SCIENCESx Basic Medicinex Immunology in the medical area0 (SwePub)301102 hsv//eng |
| 653 | a house-dust mite; factor-kappa-b; allergen fel-d-1; inflammatory response; lipocalin proteins; major allergen; amino-acid; asthma; lung; expression | |
| 700 | 1 | a Grönlund, Hansu Karolinska Institutet4 aut |
| 700 | 1 | a Gafvelin, Gurou Karolinska Institutet4 aut |
| 700 | 1 | a Bucht, Andersu Umeå universitet,Lungmedicin4 aut0 (Swepub:umu)anbu0006 |
| 710 | 2 | a Umeå universitetb Lungmedicin4 org |
| 773 | 0 | t International Archives of Allergy and Immunologyd : S. Karger AGg 155:2, s. 111-118q 155:2<111-118x 1018-2438x 1423-0097 |
| 856 | 4 | u https://www.karger.com/Article/Pdf/318743 |
| 856 | 4 8 | u https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-39542 |
| 856 | 4 8 | u https://doi.org/10.1159/000318743 |
| 856 | 4 8 | u http://kipublications.ki.se/Default.aspx?queryparsed=id:122656720 |
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