id:"swepub:oai:DiVA.org:umu-3988"
Search: id:"swepub:oai:DiVA.org:umu-3988" > Loss of hyaluronan ...
- 1 of 1
- Previous record
- Next record
- To hitlist
Loss of hyaluronan in the basement membrane zone of the skin correlates to the degree of stiff hands in diabetes patients
-
- Bertheim, Ulf (author)
- Umeå universitet,Institutionen för klinisk vetenskap
-
- Engström-Laurent, Anna (author)
- Umeå universitet,Institutionen för folkhälsa och klinisk medicin
-
- Hofer, Per-Åke (author)
- Umeå universitet,Dermatologi och venereologi
- show more...
- Hallgren, Peter (author)
- Asplund, Johan (author)
- show less...
- (creator_code:org_t)
- Medical Journals Sweden AB, 2002
- 2002
- English.
- In: Acta Dermato-Venereologica. - : Medical Journals Sweden AB. - 0001-5555 .- 1651-2057. ; 82:5, s. 329-334
- Journal article (peer-reviewed)
Abstract
Subject headings
Close
- Glycosaminoglycans are important components of all extracellular matrices. One of the glycosaminoglycans is hyaluronan, which is ubiquitously distributed throughout the connective tissue. Hyaluronan is especially abundant in the skin, in which it is of both structural and functional importance. This study describes the localization and distribution of hyaluronan in the skin of healthy individuals and of 23 patients with insulin-dependent diabetes mellitus and various degrees of limited joint mobility. In normal skin, hyaluronan staining was seen in all layers but most prominently in the papillary dermis and the basement membrane zone. In the skin from diabetic patients with normal or only moderately restricted mobility of the hands (limited joint mobility grades 0 and 1), the distribution of hyaluronan was similar to that of normal skin. In the skin of patients with severe restriction in joint mobility (limited joint mobility grade 2) the staining pattern was significantly different with weak hyaluronan staining in the papillary dermis and the basement membrane zone almost devoid of hyaluronan. Moreover, an increased epidermal thickness in the latter patients was evident as well as a pronounced hyaluronan staining compared with normal epidermis.
Keyword
- diabetes
- hyaluronan
- skin
- limited joint mobility
Publication and Content Type
- ref (subject category)
- art (subject category)
Find in a library
- Acta Dermato-Venereologica (Search for host publication in LIBRIS)
To the university's database
- 1 of 1
- Previous record
- Next record
- To hitlist
Find more in SwePub
- By the author/editor
- Bertheim, Ulf
- Engström-Laurent ...
- Hofer, Per-Åke
- Hallgren, Peter
- Asplund, Johan
- Hellström, Sten
- Articles in the publication
- Acta Dermato-Ven ...
- By the university
- Umeå University
Search outside SwePub
- Extend your search to:
- Google Book Search
- Google Scholar
Kungliga biblioteket hanterar dina personuppgifter i enlighet med EU:s dataskyddsförordning (2018), GDPR. Läs mer om hur det funkar här.
Så här hanterar KB dina uppgifter vid användning av denna tjänst.
- Copyright © LIBRIS - National Library Systems
- LIBRIS.kb.se
