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VKORC1-1639G>A, CYP2C9, EPHX1691A>G genotype, body weight, and age are important predictors for warfarin maintenance doses in patients with mechanical heart valve prostheses in southwest China
- Gu, Qiang (author)
- Kong, Yan (author)
-
- Schneede, Jörn (author)
- Umeå universitet,Klinisk kemi,Klinisk farmakologi
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- Xiao, Ying-Bin (author)
- Chen, Lin (author)
- Zhong, Qian-Jin (author)
- Wang, Xue-Feng (author)
- Hao, Jia (author)
- Chen, Bai-Cheng (author)
- Chen, Jing-Jin (author)
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- (creator_code:org_t)
- 2010-09-15
- 2010
- English.
- In: European Journal of Clinical Pharmacology. - : Springer Science and Business Media LLC. - 0031-6970 .- 1432-1041. ; 66:12, s. 1217-1227
- Journal article (peer-reviewed)
Abstract
Subject headings
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- There were great interindividual differences in warfarin maintenance dosage (ranging from 0.6 to 8.4 mg/day) among the 127 patients with mechanical heart valve prostheses. VKORC1-1639G>A, CYP2C9, EPHX1691A>G polymorphism, body weight, and age were found to affect the dose demands. Multiple linear regression models incorporating genetic polymorphisms of VKORC1, CYP2C9, EPHX1691A>G, and the nongenetic factors of age and body weight were developed, and explained up to 76.8% of the total variation (adjusted R (2) of 0.743) in warfarin maintenance doses in southwest Chinese patients with mechanical heart valve prostheses.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Annan klinisk medicin (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Other Clinical Medicine (hsv//eng)
Keyword
- Gene polymorphism
- Warfarin therapy
- SNP
- CYP2C9
- VKORC1-1639G>A
- EPHX1691A>G
- Southwest Han Chinese patients
- Mechanical heart valve prostheses
- Clinical chemistry
- Klinisk kemi
- Clinical Chemistry
- klinisk kemi
Publication and Content Type
- ref (subject category)
- art (subject category)
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- Gu, Qiang
- Kong, Yan
- Schneede, Jörn
- Xiao, Ying-Bin
- Chen, Lin
- Zhong, Qian-Jin
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- Wang, Xue-Feng
- Hao, Jia
- Chen, Bai-Cheng
- Chen, Jing-Jin
- show less...
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- MEDICAL AND HEALTH SCIENCES
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- Umeå University
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