id:"swepub:oai:DiVA.org:umu-43181"
Sökning: id:"swepub:oai:DiVA.org:umu-43181" > Aurora kinases A an...
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| Fältnamn | Indikatorer | Metadata |
|---|---|---|
| 000 | 03420naa a2200601 4500 | |
| 001 | oai:DiVA.org:umu-43181 | |
| 003 | SwePub | |
| 008 | 110422s2010 | |||||||||||000 ||eng| | |
| 024 | 7 | a https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-431812 URI |
| 024 | 7 | a https://doi.org/10.1182/blood-2009-11-2510742 DOI |
| 040 | a (SwePub)umu | |
| 041 | a engb eng | |
| 042 | 9 SwePub | |
| 072 | 7 | a ref2 swepub-contenttype |
| 072 | 7 | a art2 swepub-publicationtype |
| 100 | 1 | a den Hollander, J4 aut |
| 245 | 1 0 | a Aurora kinases A and B are up-regulated by Myc and are essential for maintenance of the malignant state |
| 264 | 1 | b American Society of Hematology,c 2010 |
| 338 | a print2 rdacarrier | |
| 520 | a Myc oncoproteins promote continuous cell growth, in part by controlling the transcription of key cell cycle regulators. Here, we report that c-Myc regulates the expression of Aurora A and B kinases (Aurka and Aurkb), and that Aurka and Aurkb transcripts and protein levels are highly elevated in Myc-driven B-cell lymphomas in both mice and humans. The induction of Aurka by Myc is transcriptional and is directly mediated via E-boxes, whereas Aurkb is regulated indirectly. Blocking Aurka/b kinase activity with a selective Aurora kinase inhibitor triggers transient mitotic arrest, polyploidization, and apoptosis of Myc-induced lymphomas. These phenotypes are selectively bypassed by a kinase inhibitor-resistant-Aurkb mutant, demonstrating that Aurkb is the primary therapeutic target in the context of Myc. Importantly, apoptosis provoked by Aurk inhibition was p53 independent, suggesting that Aurka/Aurkb inhibitors will show efficacy in treating primary or relapsed malignancies having Myc involvement and/or loss of p53 function. (Blood. 2010;116(9):1498-1505) | |
| 650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Hematologi0 (SwePub)302022 hsv//swe |
| 650 | 7 | a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Hematology0 (SwePub)302022 hsv//eng |
| 653 | a c-myc | |
| 653 | a transcriptional control | |
| 653 | a dna-replication | |
| 653 | a growth arrest | |
| 653 | a target genes | |
| 653 | a in-vivo | |
| 653 | a apoptosis | |
| 653 | a suppression | |
| 653 | a progression | |
| 653 | a inhibitor | |
| 700 | 1 | a Rimpi, Sarau Umeå universitet,Institutionen för molekylärbiologi (Teknisk-naturvetenskaplig fakultet)4 aut0 (Swepub:umu)saarii98 |
| 700 | 1 | a Doherty, JR4 aut |
| 700 | 1 | a Rudelius, M4 aut |
| 700 | 1 | a Buck, A4 aut |
| 700 | 1 | a Hoellein, A4 aut |
| 700 | 1 | a Kremer, M4 aut |
| 700 | 1 | a Graf, N4 aut |
| 700 | 1 | a Scheerer, M4 aut |
| 700 | 1 | a Hall, MA4 aut |
| 700 | 1 | a Goga, A4 aut |
| 700 | 1 | a von Bubnoff, N4 aut |
| 700 | 1 | a Duyster, J4 aut |
| 700 | 1 | a Peschel, C4 aut |
| 700 | 1 | a Cleveland, JL4 aut |
| 700 | 1 | a Nilsson, Jonas Au Umeå universitet,Institutionen för molekylärbiologi (Teknisk-naturvetenskaplig fakultet)4 aut0 (Swepub:umu)josnin95 |
| 700 | 1 | a Keller, U4 aut |
| 710 | 2 | a Umeå universitetb Institutionen för molekylärbiologi (Teknisk-naturvetenskaplig fakultet)4 org |
| 773 | 0 | t Bloodd : American Society of Hematologyg 116:9, s. 1498-1505q 116:9<1498-1505x 0006-4971x 1528-0020 |
| 856 | 4 | u https://europepmc.org/articles/pmc2938839 |
| 856 | 4 8 | u https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-43181 |
| 856 | 4 8 | u https://doi.org/10.1182/blood-2009-11-251074 |
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