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Evolution and class...
Evolution and classification of the CRISPR-Cas systems
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Makarova, Kira S (author)
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Haft, Daniel H (author)
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Barrangou, Rodolphe (author)
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Brouns, Stan J J (author)
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- Charpentier, Emmanuelle (author)
- Umeå universitet,Umeå Centre for Microbial Research (UCMR),Molekylär Infektionsmedicin, Sverige (MIMS),Institutionen för molekylärbiologi (Medicinska fakulteten),Charpentier
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Horvath, Philippe (author)
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Moineau, Sylvain (author)
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Mojica, Francisco J M (author)
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Wolf, Yuri I (author)
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Yakunin, Alexander F (author)
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van der Oost, John (author)
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Koonin, Eugene V (author)
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(creator_code:org_t)
- 2011-05-09
- 2011
- English.
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In: Nature Reviews Microbiology. - : Nature Publishing Group. - 1740-1526 .- 1740-1534. ; 9:6, s. 467-477
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https://europepmc.or...
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
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- The CRISPR-Cas (clustered regularly interspaced short palindromic repeats-CRISPR-associated proteins) modules are adaptive immunity systems that are present in many archaea and bacteria. These defence systems are encoded by operons that have an extraordinarily diverse architecture and a high rate of evolution for both the cas genes and the unique spacer content. Here, we provide an updated analysis of the evolutionary relationships between CRISPR-Cas systems and Cas proteins. Three major types of CRISPR-Cas system are delineated, with a further division into several subtypes and a few chimeric variants. Given the complexity of the genomic architectures and the extremely dynamic evolution of the CRISPR-Cas systems, a unified classification of these systems should be based on multiple criteria. Accordingly, we propose a 'polythetic' classification that integrates the phylogenies of the most common cas genes, the sequence and organization of the CRISPR repeats and the architecture of the CRISPR-cas loci.
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- By the author/editor
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Makarova, Kira S
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Haft, Daniel H
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Barrangou, Rodol ...
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Brouns, Stan J J
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Charpentier, Emm ...
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Horvath, Philipp ...
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show more...
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Moineau, Sylvain
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Mojica, Francisc ...
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Wolf, Yuri I
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Yakunin, Alexand ...
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van der Oost, Jo ...
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Koonin, Eugene V
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show less...
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Nature Reviews M ...
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Umeå University