SwePub
Sök i LIBRIS databas

  Utökad sökning

id:"swepub:oai:DiVA.org:umu-47664"
 

Sökning: id:"swepub:oai:DiVA.org:umu-47664" > Asthmatics exhibit ...

LIBRIS Formathandbok  (Information om MARC21)
FältnamnIndikatorerMetadata
00004430naa a2200481 4500
001oai:DiVA.org:umu-47664
003SwePub
008110927s2011 | |||||||||||000 ||eng|
009oai:prod.swepub.kib.ki.se:123215832
0247 a https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-476642 URI
0247 a https://doi.org/10.1371/journal.pone.00238642 DOI
0247 a http://kipublications.ki.se/Default.aspx?queryparsed=id:1232158322 URI
040 a (SwePub)umud (SwePub)ki
041 a engb eng
042 9 SwePub
072 7a ref2 swepub-contenttype
072 7a art2 swepub-publicationtype
1001 a Lundström, Susanna L.u Karolinska Institutet4 aut
2451 0a Asthmatics exhibit altered oxylipin profiles compared to healthy individuals after subway air exposure
264 c 2011-08-29
264 1a San Francisco, CA :b Public Library of Science,c 2011
338 a print2 rdacarrier
520 a Background: Asthma is a chronic inflammatory lung disease that causes significant morbidity and mortality worldwide. Air pollutants such as particulate matter (PM) and oxidants are important factors in causing exacerbations in asthmatics, and the source and composition of pollutants greatly affects pathological implications.Objectives: This randomized crossover study investigated responses of the respiratory system to Stockholm subway air in asthmatics and healthy individuals. Eicosanoids and other oxylipins were quantified in the distal lung to provide a measure of shifts in lipid mediators in association with exposure to subway air relative to ambient air.Methods: Sixty-four oxylipins representing the cyclooxygenase (COX), lipoxygenase (LOX) and cytochrome P450 (CYP) metabolic pathways were screened using liquid chromatography-tandem mass spectrometry (LC-MS/MS) of bronchoalveolar lavage (BAL)-fluid. Validations through immunocytochemistry staining of BAL-cells were performed for 15-LOX-1, COX-1, COX-2 and peroxisome proliferator-activated receptor gamma (PPAR gamma). Multivariate statistics were employed to interrogate acquired oxylipin and immunocytochemistry data in combination with patient clinical information.Results: Asthmatics and healthy individuals exhibited divergent oxylipin profiles following exposure to ambient and subway air. Significant changes were observed in 8 metabolites of linoleic- and alpha-linolenic acid synthesized via the 15-LOX pathway, and of the COX product prostaglandin E(2) (PGE(2)). Oxylipin levels were increased in healthy individuals following exposure to subway air, whereas asthmatics evidenced decreases or no change.Conclusions: Several of the altered oxylipins have known or suspected bronchoprotective or anti-inflammatory effects, suggesting a possible reduced anti-inflammatory response in asthmatics following exposure to subway air. These observations may have ramifications for sensitive subpopulations in urban areas.
650 7a NATURVETENSKAPx Biologi0 (SwePub)1062 hsv//swe
650 7a NATURAL SCIENCESx Biological Sciences0 (SwePub)1062 hsv//eng
7001 a Levanen, Bettinau Karolinska Institutet4 aut
7001 a Nording, Malinu Umeå universitet,Lungmedicin4 aut0 (Swepub:umu)mano0003
7001 a Klepczynska-Nystrom, Annau Karolinska Institutet4 aut
7001 a Sköld, Magnusu Karolinska Institutet4 aut
7001 a Haeggström, Jesper Z.u Karolinska Institutet4 aut
7001 a Grunewald, Johanu Karolinska Institutet4 aut
7001 a Svartengren, Magnusu Karolinska Institutet4 aut
7001 a Hammock, Bruce D.u Department of Entomology and Cancer Research Center, University of California Davis, Davis, California, United States of America4 aut
7001 a Larsson, Britt-Marieu Karolinska Institutet4 aut
7001 a Eklund, Andersu Karolinska Institutet4 aut
7001 a Wheelock, Åsa M.u Karolinska Institutet4 aut
7001 a Wheelock, Craig E.u Karolinska Institutet4 aut
7102 a Karolinska Institutetb Lungmedicin4 org
7730 t PLOS ONEd San Francisco, CA : Public Library of Scienceg 6:8, s. e23864-q 6:8<e23864-x 1932-6203
8564 u https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0023864&type=printable
8564 8u https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-47664
8564 8u https://doi.org/10.1371/journal.pone.0023864
8564 8u http://kipublications.ki.se/Default.aspx?queryparsed=id:123215832

Hitta via bibliotek

  • PLOS ONE (Sök värdpublikationen i LIBRIS)

Till lärosätets databas

Kungliga biblioteket hanterar dina personuppgifter i enlighet med EU:s dataskyddsförordning (2018), GDPR. Läs mer om hur det funkar här.
Så här hanterar KB dina uppgifter vid användning av denna tjänst.

 
pil uppåt Stäng

Kopiera och spara länken för att återkomma till aktuell vy