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Human primary bronc...
Human primary bronchial epithelial cells respond differently to titanium dioxide nanoparticles than the lung epithelial cell lines A549 and BEAS-2B
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Ekstrand-Hammarström, Barbro (author)
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Akfur, Christine M (author)
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Andersson, Per Ola (author)
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Lejon, Christian (author)
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Österlund, Lars (author)
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- Bucht, Anders (author)
- Umeå universitet,Lungmedicin
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(creator_code:org_t)
- 2011-07-25
- 2012
- English.
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In: Nanotoxicology. - : Informa UK Limited. - 1743-5390 .- 1743-5404. ; 6:6, s. 623-634
- Related links:
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https://urn.kb.se/re...
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https://doi.org/10.3...
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Abstract
Subject headings
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- We have compared the cellular uptake and responses of five preparations of nanocrystalline titanium dioxide (TiO(2)) between normal human bronchial epithelial (NHBE) cells and epithelial cell lines (A549 and BEAS-2B). The P25 nanoparticles, containing both anatase and rutile modifications, induced reactive oxygen species (ROS) and secretion of the neutrophil chemoattractant IL-8 in all three cell types used. Pure anatase and rutile particles provoked differential IL-8 response in A549 and no response in BEAS-2B cells despite similar formation of ROS. The pure TiO(2) modifications also provoked release of the inflammatory mediators: IL-6, G-CSF and VEGF, in NHBE cells but not in the two cell lines. We conclude that the responsiveness of lung epithelial cells is strongly dependent on both the physicochemical properties of TiO(2) nanoparticles and the type of responder cells. The differential pro-inflammatory responsiveness of primary lung epithelial cells compared with immortalized cell lines should be considered in the assessment of adverse reactions to inhaled nanoparticles.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Lungmedicin och allergi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Respiratory Medicine and Allergy (hsv//eng)
Keyword
- TiO2 nanoparticles
- normal human bronchial
- epithelial cells
- rutile
- anatase
- inflammation
Publication and Content Type
- ref (subject category)
- art (subject category)
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