Search: id:"swepub:oai:DiVA.org:umu-51943" >
Prognostic signific...
Prognostic significance of additional cytogenetic aberrations in 733 de novo pediatric 11q23/MLL-rearranged AML patients : results of an international study
-
Coenen, Eva A (author)
-
Raimondi, Susana C (author)
-
Harbott, Jochen (author)
-
show more...
-
Zimmermann, Martin (author)
-
Alonzo, Todd A (author)
-
Auvrignon, Anne (author)
-
Beverloo, H Berna (author)
-
Chang, Myron (author)
-
Creutzig, Ursula (author)
-
Dworzak, Michael N (author)
-
- Forestier, Erik (author)
- Umeå universitet,Pediatrik
-
Gibson, Brenda (author)
-
Hasle, Henrik (author)
-
Harrison, Christine J (author)
-
Heerema, Nyla A (author)
-
Kaspers, Gertjan J L (author)
-
Leszl, Anna (author)
-
Litvinko, Nathalia (author)
-
Lo Nigro, Luca (author)
-
Morimoto, Akira (author)
-
Perot, Christine (author)
-
Reinhardt, Dirk (author)
-
Rubnitz, Jeffrey E (author)
-
Smith, Franklin O (author)
-
Stary, Jan (author)
-
Stasevich, Irina (author)
-
Strehl, Sabine (author)
-
Taga, Takashi (author)
-
Tomizawa, Daisuke (author)
-
Webb, David (author)
-
Zemanova, Zuzana (author)
-
Pieters, Rob (author)
-
Zwaan, C Michel (author)
-
van den Heuvel-Eibrink, Marry M (author)
-
show less...
-
(creator_code:org_t)
- American Society of Hematology, 2011
- 2011
- English.
-
In: Blood. - : American Society of Hematology. - 0006-4971 .- 1528-0020. ; 117:26, s. 7102-7111
- Related links:
-
https://europepmc.or...
-
show more...
-
https://urn.kb.se/re...
-
https://doi.org/10.1...
-
show less...
Abstract
Subject headings
Close
- We previously demonstrated that outcome of pediatric 11q23/MLL-rearranged AML depends on the translocation partner (TP). In this multicenter international study on 733 children with 11q23/MLL-rearranged AML, we further analyzed which additional cytogenetic aberrations (ACA) had prognostic significance. ACAs occurred in 344 (47%) of 733 and were associated with unfavorable outcome (5-year overall survival [OS] 47% vs 62%, P < .001). Trisomy 8, the most frequent specific ACA (n = 130/344, 38%), independently predicted favorable outcome within the ACAs group (OS 61% vs 39%, P = .003; Cox model for OS hazard ratio (HR) 0.54, P = .03), on the basis of reduced relapse rate (26% vs 49%, P < .001). Trisomy 19 (n = 37/344, 11%) independently predicted poor prognosis in ACAs cases, which was partly caused by refractory disease (remission rate 74% vs 89%, P = .04; OS 24% vs 50%, P < .001; HR 1.77, P = .01). Structural ACAs had independent adverse prognostic value for event-free survival (HR 1.36, P = .01). Complex karyotype, defined as ≥ 3 abnormalities, was present in 26% (n = 192/733) and showed worse outcome than those without complex karyotype (OS 45% vs 59%, P = .003) in univariate analysis only. In conclusion, like TP, specific ACAs have independent prognostic significance in pediatric 11q23/MLL-rearranged AML, and the mechanism underlying these prognostic differences should be studied.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Pediatrik (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Pediatrics (hsv//eng)
Publication and Content Type
- ref (subject category)
- art (subject category)
Find in a library
-
Blood
(Search for host publication in LIBRIS)
To the university's database
- By the author/editor
-
Coenen, Eva A
-
Raimondi, Susana ...
-
Harbott, Jochen
-
Zimmermann, Mart ...
-
Alonzo, Todd A
-
Auvrignon, Anne
-
show more...
-
Beverloo, H Bern ...
-
Chang, Myron
-
Creutzig, Ursula
-
Dworzak, Michael ...
-
Forestier, Erik
-
Gibson, Brenda
-
Hasle, Henrik
-
Harrison, Christ ...
-
Heerema, Nyla A
-
Kaspers, Gertjan ...
-
Leszl, Anna
-
Litvinko, Nathal ...
-
Lo Nigro, Luca
-
Morimoto, Akira
-
Perot, Christine
-
Reinhardt, Dirk
-
Rubnitz, Jeffrey ...
-
Smith, Franklin ...
-
Stary, Jan
-
Stasevich, Irina
-
Strehl, Sabine
-
Taga, Takashi
-
Tomizawa, Daisuk ...
-
Webb, David
-
Zemanova, Zuzana
-
Pieters, Rob
-
Zwaan, C Michel
-
van den Heuvel-E ...
-
show less...
- About the subject
-
- MEDICAL AND HEALTH SCIENCES
-
MEDICAL AND HEAL ...
-
and Clinical Medicin ...
-
and Pediatrics
- Articles in the publication
-
Blood
- By the university
-
Umeå University