Emerging knowledge of regulatory roles of D-amino acids in bacteria

Cava, Felipe (author): Channing Laboratory, Brigham and Women’s Hospital, Harvard Medical School, and Howard Hughes Medical Institute, Boston, USA

Lam, Hubert (author): Channing Laboratory, Brigham and Women’s Hospital, Harvard Medical School, and Howard Hughes Medical Institute, Boston, USA

de Pedro, Miguel A (author): Centro de Biología Molecular "Severo Ochoa" Consejo Superior de Investigaciones Cientíﬁcas, Universidad Autónoma de Madrid, Spain

Waldor, Matthew K (author): Channing Laboratory, Brigham and Women’s Hospital, Harvard Medical School, and Howard Hughes Medical Institute, Boston, USA

(creator_code:org_t)

2010-12-14
2011
English.
In: Cellular and Molecular Life Sciences (CMLS). - : Springer Science and Business Media LLC. - 1420-682X .- 1420-9071. ; 68:5, s. 817-831

Related links:: https://umu.diva-por... (primary) (Raw object); show more...; https://link.springe...; https://urn.kb.se/re...; https://doi.org/10.1...; show less...

Abstract Subject headings

The D-enantiomers of amino acids have been thought to have relatively minor functions in biological processes. While L-amino acids clearly predominate in nature, D-amino acids are sometimes found in proteins that are not synthesized by ribosomes, and D-Ala and D-Glu are routinely found in the peptidoglycan cell wall of bacteria. Here, we review recent findings showing that D-amino acids have previously unappreciated regulatory roles in the bacterial kingdom. Many diverse bacterial phyla synthesize and release D-amino acids, including D-Met and D-Leu, which were not previously known to be made. These noncanonical D-amino acids regulate cell wall remodeling in stationary phase and cause biofilm dispersal in aging bacterial communities. Elucidating the mechanisms by which D-amino acids govern cell wall remodeling and biofilm disassembly will undoubtedly reveal new paradigms for understanding how extracytoplasmic processes are regulated as well as lead to development of novel therapeutics.

By the author/editor: Cava, Felipe; Lam, Hubert; de Pedro, Miguel ...; Waldor, Matthew ...

About the subject

MEDICAL AND HEALTH SCIENCES: MEDICAL AND HEAL ...; and Medical Biotechn ...; and Medical Biotechn ...

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