id:"swepub:oai:DiVA.org:umu-81861"
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| Fältnamn | Indikatorer | Metadata |
|---|---|---|
| 000 | 03524naa a2200421 4500 | |
| 001 | oai:DiVA.org:umu-81861 | |
| 003 | SwePub | |
| 008 | 131022s2011 | |||||||||||000 ||eng| | |
| 024 | 7 | a https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-818612 URI |
| 024 | 7 | a https://doi.org/10.1007/s00018-010-0571-82 DOI |
| 040 | a (SwePub)umu | |
| 041 | a engb eng | |
| 042 | 9 SwePub | |
| 072 | 7 | a ref2 swepub-contenttype |
| 072 | 7 | a art2 swepub-publicationtype |
| 100 | 1 | a Cava, Felipeu Channing Laboratory, Brigham and Women’s Hospital, Harvard Medical School, and Howard Hughes Medical Institute, Boston, USA4 aut0 (Swepub:umu)feca0003 |
| 245 | 1 0 | a Emerging knowledge of regulatory roles of D-amino acids in bacteria |
| 264 | c 2010-12-14 | |
| 264 | 1 | b Springer Science and Business Media LLC,c 2011 |
| 338 | a electronic2 rdacarrier | |
| 520 | a The D-enantiomers of amino acids have been thought to have relatively minor functions in biological processes. While L-amino acids clearly predominate in nature, D-amino acids are sometimes found in proteins that are not synthesized by ribosomes, and D-Ala and D-Glu are routinely found in the peptidoglycan cell wall of bacteria. Here, we review recent findings showing that D-amino acids have previously unappreciated regulatory roles in the bacterial kingdom. Many diverse bacterial phyla synthesize and release D-amino acids, including D-Met and D-Leu, which were not previously known to be made. These noncanonical D-amino acids regulate cell wall remodeling in stationary phase and cause biofilm dispersal in aging bacterial communities. Elucidating the mechanisms by which D-amino acids govern cell wall remodeling and biofilm disassembly will undoubtedly reveal new paradigms for understanding how extracytoplasmic processes are regulated as well as lead to development of novel therapeutics. | |
| 650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Medicinsk bioteknologix Medicinsk bioteknologi0 (SwePub)304012 hsv//swe |
| 650 | 7 | a MEDICAL AND HEALTH SCIENCESx Medical Biotechnologyx Medical Biotechnology0 (SwePub)304012 hsv//eng |
| 653 | a D-amino acid | |
| 653 | a racemase | |
| 653 | a stationary phase | |
| 653 | a peptidoglycan | |
| 653 | a biofilm | |
| 653 | a regulation | |
| 700 | 1 | a Lam, Hubertu Channing Laboratory, Brigham and Women’s Hospital, Harvard Medical School, and Howard Hughes Medical Institute, Boston, USA4 aut |
| 700 | 1 | a de Pedro, Miguel Au Centro de Biología Molecular "Severo Ochoa" Consejo Superior de Investigaciones Científicas, Universidad Autónoma de Madrid, Spain4 aut |
| 700 | 1 | a Waldor, Matthew Ku Channing Laboratory, Brigham and Women’s Hospital, Harvard Medical School, and Howard Hughes Medical Institute, Boston, USA4 aut |
| 710 | 2 | a Channing Laboratory, Brigham and Women’s Hospital, Harvard Medical School, and Howard Hughes Medical Institute, Boston, USAb Centro de Biología Molecular "Severo Ochoa" Consejo Superior de Investigaciones Científicas, Universidad Autónoma de Madrid, Spain4 org |
| 773 | 0 | t Cellular and Molecular Life Sciences (CMLS)d : Springer Science and Business Media LLCg 68:5, s. 817-831q 68:5<817-831x 1420-682Xx 1420-9071 |
| 856 | 4 | u https://umu.diva-portal.org/smash/get/diva2:658605/FULLTEXT01.pdfx primaryx Raw objecty fulltext:print |
| 856 | 4 | u https://link.springer.com/content/pdf/10.1007%2Fs00018-010-0571-8.pdf |
| 856 | 4 8 | u https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-81861 |
| 856 | 4 8 | u https://doi.org/10.1007/s00018-010-0571-8 |
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