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Subcutaneous implanted chambers in different mouse strains as an animal model to study genetic stability during infection with Lyme disease Borrelia
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- Jonsson, Maria (author)
- Umeå universitet,Mikrobiologi
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- Elmros, Teodor (author)
- Umeå universitet,Mikrobiologi
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- Bergström, Sven (author)
- Umeå universitet,Mikrobiologi
- (creator_code:org_t)
- Academic Press, 1995
- 1995
- English.
- In: Microbial Pathogenesis. - : Academic Press. - 0882-4010 .- 1096-1208. ; 18:2, s. 109-14
- Journal article (peer-reviewed)
Abstract
Subject headings
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- Tissue metal net cages were implanted subcutaneously in BALB/cJ and C3H/Tif mice as an experimental model of Borrelia burgdorferi infection. B. burgdorferi sensu stricto strain Sh2-82 could be isolated up to 14 weeks after the inoculation. However, a significant difference in infectivity between the two mice strains was observed. C3H/Tif mice were more susceptible to developing chronic B. burgdorferi s.s. infections than BALB/cJ mice. Although a B. burgdorferi infection was established, no rearrangements in the ospA and ospB genes were observed in any of the infected mice.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Immunologi inom det medicinska området (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Immunology in the medical area (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Mikrobiologi inom det medicinska området (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Microbiology in the medical area (hsv//eng)
Keyword
- Borrelia burgdorferi
- ospAB operon
- genetic stability
- subcutaneous chambers
Publication and Content Type
- ref (subject category)
- art (subject category)
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