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Four-Component Asse...
Four-Component Assembly of Natural-Product-Like Ring-Fused Isoquinuclidines
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- Sellstedt, Magnus (author)
- Umeå universitet,Kemiska institutionen
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- Dang, Hung The (author)
- Umeå universitet,Kemiska institutionen
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- Prasad, G. Krishna (author)
- Umeå universitet,Kemiska institutionen
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- Sauer, Uwe (author)
- Umeå universitet,Kemiska institutionen
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- Almqvist, Fredrik (author)
- Umeå universitet,Kemiska institutionen
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(creator_code:org_t)
- 2013-10-21
- 2013
- English.
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In: European Journal of Organic Chemistry. - : John Wiley & Sons. - 1434-193X .- 1099-0690. ; 2013:33, s. 7476-7479
- Related links:
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
Subject headings
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- A four-component reaction between formyl-substituted 2-pyridones, aldehydes, amines, and activated alkenes has been developed. The resulting products are ring-fused natural-product-like isoquinuclidines. Three carbon–carbon bonds, two carbon–nitrogen bonds, and four or five stereocentres are formed in the reaction with overall product yields in the range 23–67 %. In most cases a single diastereomer was obtained. An intramolecular version of the reaction yielded analogues of the multi-ring-fused natural product catharanthine in a single step.
Subject headings
- NATURVETENSKAP -- Kemi (hsv//swe)
- NATURAL SCIENCES -- Chemical Sciences (hsv//eng)
Keyword
- multicomponent reactions
- natural products
- fused-ring systems
- nitrogen heterocycles
Publication and Content Type
- ref (subject category)
- art (subject category)
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