n-3 Fatty acids are positively associated with peak bone mineral density and bone accrual in healthy men: the NO2 Study

n-3 Fatty acids are positively associated with peak bone mineral density and bone accrual in healthy men : the NO2 Study

Nordström, Peter (author): Umeå universitet,Idrottsmedicin,Institutionen för folkhälsa och klinisk medicin

Nordström, Anna (author): Umeå universitet,Idrottsmedicin,Institutionen för samhällsmedicin och rehabilitering

(creator_code:org_t)

American Society for Clinical Nutrition, 2007
2007
English.
In: American Journal of Clinical Nutrition. - : American Society for Clinical Nutrition. - 0002-9165 .- 1938-3207. ; 85:3, s. 803-807

Related links:: http://ajcn.nutritio...; show more...; https://urn.kb.se/re...; show less...

Abstract Subject headings

Background:Knowledge of the influence of nutritional intake on bone health is limited. Polyunsaturated fatty acids have been suggested to influence bone growth and modeling in humans, although data are sparse.Objective:The objective was to investigate the role of fatty acids in bone accumulation and the attainment of peak bone mass in young men.Design:The cohort studied consisted of 78 healthy young men with a mean age of 16.7 y at baseline. Bone mineral density (BMD; in g/cm2) of total body, hip, and spine was measured at baseline and at 22 and 24 y of age. Fatty acid concentrations were measured in the phospholipid fraction in serum at 22 y of age.Results:Concentrations of n−3 fatty acids were positively associated with total BMD (r = 0.27, P = 0.02) and spine BMD (r = 0.25, P = 0.02) at 22 y of age. A positive correlation between n−3 fatty acid concentrations and the changes in BMD at the spine (r = 0.26, P = 0.02) was found between 16 and 22 y of age. Concentrations of docosahexaenoic acid (DHA, 22:6n−3) were positively associated with total BMD (r = 0.32, P = 0.004) and BMD at the spine (r = 0.30, P = 0.008) at 22 y of age. A positive correlation was also found between DHA concentrations and the changes in BMD at the spine (r = 0.26, P = 0.02) between 16 and 22 y of age.Conclusion:The results showed that n−3 fatty acids, especially DHA, are positively associated with bone mineral accrual and, thus, with peak BMD in young men.

About the subject

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