Type 3 cystatins: fetuins, kininogen and histidine-rich glycoprotein

Type 3 cystatins : fetuins, kininogen and histidine-rich glycoprotein

Lee, Chunsik (author): Uppsala universitet,Institutionen för genetik och patologi

Bongcam Rudloff, Erik (author): Swedish University of Agricultural Sciences,Sveriges lantbruksuniversitet,Institutionen för husdjursgenetik (HGEN),Department of Animal Breeding and Genetics

Sollner, Christian (author)

Jahnen-Dechent, Willi (author)

Claesson-Welsh, Lena (author): Uppsala universitet,Institutionen för genetik och patologi

(creator_code:org_t)

IMR Press, 2009
2009
English.
In: Frontiers in Bioscience. - : IMR Press. - 1093-9946 .- 1093-4715. ; 14, s. 2911-2922

Related links:: https://urn.kb.se/re...; show more...; https://doi.org/10.2...; https://res.slu.se/i...; show less...

Abstract Subject headings

This review describes the properties of four structurally related, abundant plasma proteins denoted fetuin-A/alpha-2-Heremans Schmid-glycoprotein (AHSG), fetuin-B (FETUB), kininogen (KNG) and histidine-rich glycoprotein (HRG). These proteins form a subgroup (denoted type 3) within the cystatin superfamily of cysteine protease inhibitors. Apart from KNG, the type 3 proteins appear to lack cystatin activity. AHSG has its major function in regulation of bone mineralization; the physiological role of FETUB is poorly understood. KNG serves dual functions in the assembly of the protein complex initiating the surface-activated blood coagulation cascade and as a precursor for the kinin hormones. The heparin-binding HRG has also been implicated in regulation of coagulation. In addition, several members of the type 3 cystatins have been implicated in tumor growth and shown to regulate endothelial cell function and formation of new blood vessels, angiogenesis. Thus, these proteins may potentially be useful in treatment of diseases characterized by excess angiogenesis such as cancer.

NATURVETENSKAP -- Biologi -- Biokemi och molekylärbiologi (hsv//swe)
NATURAL SCIENCES -- Biological Sciences -- Biochemistry and Molecular Biology (hsv//eng)

By the author/editor: Lee, Chunsik; Bongcam Rudloff, ...; Sollner, Christi ...; Jahnen-Dechent, ...; Claesson-Welsh, ...

About the subject

NATURAL SCIENCES: NATURAL SCIENCES; and Biological Scien ...; and Biochemistry and ...

By the university: Uppsala University; Swedish University of Agricultural Sciences

Kungliga biblioteket hanterar dina personuppgifter i enlighet med EU:s dataskyddsförordning (2018), GDPR. Läs mer om hur det funkar här.
Så här hanterar KB dina uppgifter vid användning av denna tjänst.