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FältnamnIndikatorerMetadata
00004355naa a2200517 4500
001oai:DiVA.org:uu-102842
003SwePub
008090512s2009 | |||||||||||000 ||eng|
009oai:lup.lub.lu.se:19c68aa4-d35c-4416-9844-3b71fa9df3f0
0247 a https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-1028422 URI
0247 a https://doi.org/10.1002/art.242442 DOI
0247 a https://lup.lub.lu.se/record/13750922 URI
040 a (SwePub)uud (SwePub)lu
041 a engb eng
042 9 SwePub
072 7a ref2 swepub-contenttype
072 7a art2 swepub-publicationtype
1001 a Orozco, Gisela4 aut
2451 0a Study of functional variants of the BANK1 gene in rheumatoid arthritis
264 1b Wiley,c 2009
338 a print2 rdacarrier
520 a OBJECTIVE: To investigate 1 functional (rs17266594) and 2 potentially functional (rs10516487 and rs3733197) BANK1 variants, which were previously identified as systemic lupus erythematosus (SLE) susceptibility markers, to test whether they are associated with rheumatoid arthritis (RA). METHODS: Four different cohorts were included in the study: 1,080 RA patients and 1,368 healthy controls from Spain, 278 RA patients and 568 healthy controls from Sweden, 288 RA patients and 287 healthy controls from Argentina, and 288 RA patients and 288 healthy controls from Mexico. Samples were genotyped for BANK1 single-nucleotide polymorphisms (SNPs) using a TaqMan 5'-allele discrimination assay. Statistical analysis comparing allele and genotype distributions was performed with the chi-square test. RESULTS: We did not find a significant association between RA and the rs10516487 and rs17266594 BANK1 polymorphisms. However, there was an increase in the major alleles among RA patients. Similarly, for rs3733197, there was an increase in the major allele among patients in every cohort. Nevertheless, this skewing reached statistical significance in the Spanish (P = 0.01, odds ratio [OR] 1.17 [95% confidence interval (95% CI) 1.03-1.32]) and Argentinean (P = 0.04, OR 1.31 [95% CI 1.00-1.72]) populations. We found a significant association of rs10516487 (P = 0.005, OR 1.15 [95% CI 1.04-1.28]) and rs3733197 (P = 0.0009, OR 1.17 [95% CI 1.07-1.29]) with RA in the pooled analysis. In a 3-SNP haplotype analysis, we found that the major TGG haplotype was significantly associated with RA (P = 0.005, OR 1.14 [95% CI 1.04-1.25]). In addition, we found a common CAA haplotype that was protective against RA (P = 0.0004, OR 0.82 [95% CI 0.74-0.92]). CONCLUSION: These results suggest that BANK1 SNPs and haplotypes may contribute to RA susceptibility with a low risk.
650 7a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Reumatologi och inflammation0 (SwePub)302102 hsv//swe
650 7a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Rheumatology and Autoimmunity0 (SwePub)302102 hsv//eng
653 a MEDICINE
653 a MEDICIN
7001 a Abelson, Anna-Karinu Uppsala universitet,Institutionen för genetik och patologi4 aut0 (Swepub:uu)anive102
7001 a González-Gay, Miguel A.4 aut
7001 a Balsa, Alejandro4 aut
7001 a Pascual-Salcedo, Dora4 aut
7001 a García, Antonio4 aut
7001 a Fernández-Gutierrez, Benjamín4 aut
7001 a Petersson, Ingemaru Lund University,Lunds universitet,Ortopedi, Lund,Sektion III,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Orthopaedics (Lund),Section III,Department of Clinical Sciences, Lund,Faculty of Medicine4 aut0 (Swepub:lu)ort-ipe
7001 a Pons-Estel, Bernardo4 aut
7001 a Eimon, Alicia4 aut
7001 a Paira, Sergio4 aut
7001 a Scherbarth, Hugo R.4 aut
7001 a Alarcón-Riquelme, Martau Uppsala universitet,Institutionen för genetik och patologi4 aut0 (Swepub:uu)martaala
7001 a Martín, Javier4 aut
7102 a Uppsala universitetb Institutionen för genetik och patologi4 org
7730 t Arthritis and Rheumatismd : Wileyg 60:2, s. 372-379q 60:2<372-379x 0004-3591x 1529-0131
8564 u https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/art.24244
8564 u http://dx.doi.org/10.1002/art.24244y FULLTEXT
8564 8u https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-102842
8564 8u https://doi.org/10.1002/art.24244
8564 8u https://lup.lub.lu.se/record/1375092

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