id:"swepub:oai:DiVA.org:uu-103237"
Search: id:"swepub:oai:DiVA.org:uu-103237" > A computerized Infu...
- 1 of 1
- Previous record
- Next record
- To hitlist
A computerized Infusion Pump for control of tissue tracer concentration during Positron Emission Tomography in vivo Pharmacokinetic/Pharmacodynamic measurements
-
- Eriksson, Olof (author)
- Uppsala universitet,Enheten för radiologi
- Wallberg, Andreas (author)
-
- Syvänen, Stina (author)
- Uppsala universitet,Institutionen för farmaceutisk biovetenskap,Hammarlund-Udenaes
- show more...
- show less...
- (creator_code:org_t)
- 2008-05-30
- 2008
- English.
- In: BMC Medical Physics. - : Springer Science and Business Media LLC. - 1756-6649. ; 8:2
- Journal article (peer-reviewed)
Abstract
Subject headings
Close
- BACKGROUND:A computer controlled infusion pump (UIPump) for regulation of target tissue concentration of radioactive compounds was developed for use in biological research and tracer development for PET.METHODS:Based on observed tissue or plasma kinetics after a bolus injection of the tracer an algorithm calculates the infusion needed to obtain a specified target kinetic curve. A computer feeds this infusion scheme into an infusion pump connected to an animal via a venous catheter. The concept was validated using [11C]Flumazenil administrated to Sprague-Dawley rats where the whole brain distribution and kinetic of the tracer was measured over time using a microPET-scanner. The accuracy and precision of the system was assessed by producing steady-state levels of the tracer and by mimicking kinetics after oral administration.RESULTS:Various kinetic profiles could be generated, including rapid achievement of constant levels, or step-wise increased levels. The resulting tissue curves had low deviation from the target curves according to the specified criteria: AUC (%): 4.2 +/- 2.8, Maximal deviation (%): 13.6 +/- 5.0 and R2: 0.95 +/- 0.02.CONCLUSION:The UIPump-system is suitable for use in PET-research for assessment of PK/PD properties by simulation of different tracer tissue kinetics in vivo.
Keyword
- MEDICINE
- MEDICIN
Publication and Content Type
- ref (subject category)
- art (subject category)
Find in a library
- BMC Medical Physics (Search for host publication in LIBRIS)
To the university's database
- 1 of 1
- Previous record
- Next record
- To hitlist
Find more in SwePub
- By the author/editor
- Eriksson, Olof
- Wallberg, Andrea ...
- Syvänen, Stina
- Josephsson, Raym ...
- Långström, Bengt
- Bergström, Mats
- Articles in the publication
- BMC Medical Phys ...
- By the university
- Uppsala University
Search outside SwePub
- Extend your search to:
- Google Book Search
- Google Scholar
Kungliga biblioteket hanterar dina personuppgifter i enlighet med EU:s dataskyddsförordning (2018), GDPR. Läs mer om hur det funkar här.
Så här hanterar KB dina uppgifter vid användning av denna tjänst.
- Copyright © LIBRIS - National Library Systems
- LIBRIS.kb.se
