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Hyperglycemia and s...
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Hyvärinen, Marjukka
(författare)
Hyperglycemia and stroke mortality : comparison between fasting and 2-h glucose criteria
- Artikel/kapitelEngelska2009
Förlag, utgivningsår, omfång ...
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American Diabetes Association,2009
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printrdacarrier
Nummerbeteckningar
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LIBRIS-ID:oai:DiVA.org:uu-103477
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https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-103477URI
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https://doi.org/10.2337/dc08-1411DOI
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https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-32934URI
Kompletterande språkuppgifter
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Språk:engelska
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Sammanfattning på:engelska
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Klassifikation
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Ämneskategori:ref swepub-contenttype
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Ämneskategori:art swepub-publicationtype
Anmärkningar
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Group Author(s): DECODE Study Group
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OBJECTIVE: We investigated stroke mortality in individuals in different categories of glycemia and compared hazard ratios (HRs) corresponding to a 1-SD increase in 2-h plasma glucose and fasting plasma glucose (FPG) criteria. RESEARCH DESIGN AND METHODS: We examined data from 2-h 75-g oral glucose tolerance tests taken from 13 European cohorts comprising 11,844 (55%) men and 9,862 (45%) women who were followed up for a median of 10.5 years. A multivariate adjusted Cox proportional hazards model was used to estimate HRs for stroke mortality. RESULTS: In men and women without a prior history of diabetes, multivariate adjusted HRs for stroke mortality corresponding to a 1-SD increase in FPG were 1.02 (95% CI 0.83-1.25) and 1.52 (1.22-1.88) and those in 2-h plasma glucose 1.21 (1.06-1.38) and 1.31 (1.06-1.61), respectively. Addition of 2-h plasma glucose to the model with FPG significantly improved prediction of stroke mortality in men (chi2 = 10.12; P = 0.001) but not in women (chi2 = 0.01; P = 0.94), whereas addition of FPG to 2-h plasma glucose improved stroke mortality in women (chi2 = 4.08; P = 0.04) but not in men (chi2 = 3.29; P = 0.07). CONCLUSIONS: Diabetes defined by either FPG or 2-h plasma glucose increases the risk of stroke mortality. In individuals without a history of diabetes, elevated 2-h postchallenge glucose is a better predictor than elevated fasting glucose in men, whereas the latter is better than the former in women.
Ämnesord och genrebeteckningar
Biuppslag (personer, institutioner, konferenser, titlar ...)
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Qiao, Qing
(författare)
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Tuomilehto, Jaakko
(författare)
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Laatikainen, Tiina
(författare)
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Heine, Robert J
(författare)
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Stehouwer, Coen D A
(författare)
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Alberti, K George M M
(författare)
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Pyörälä, Kalevi
(författare)
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Zethelius, BjörnUppsala universitet,Geriatrik(Swepub:uu)bjorzeth
(författare)
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Stegmayr, BirgittaUmeå universitet,Medicin(Swepub:umu)bist0001
(författare)
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Uppsala universitetGeriatrik
(creator_code:org_t)
Sammanhörande titlar
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Ingår i:Diabetes Care: American Diabetes Association32:2, s. 348-3540149-59921935-5548
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Till lärosätets databas
- Av författaren/redakt...
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Hyvärinen, Marju ...
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Qiao, Qing
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Tuomilehto, Jaak ...
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Laatikainen, Tii ...
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Heine, Robert J
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Stehouwer, Coen ...
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visa fler...
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Alberti, K Georg ...
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Pyörälä, Kalevi
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Zethelius, Björn
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Stegmayr, Birgit ...
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visa färre...
- Artiklar i publikationen
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Diabetes Care
- Av lärosätet
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Uppsala universitet
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Umeå universitet