Associations of serum adiponectin with skeletal muscle morphology and insulin sensitivity

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Associations of serum adiponectin with skeletal muscle morphology and insulin sensitivity

Ingelsson, Erik (author): Karolinska Institutet,Uppsala universitet,Geriatrik

Ärnlöv, Johan (author): Högskolan Dalarna,Uppsala universitet,Geriatrik,Medicinsk vetenskap,Uppsala University, Department of Health and Social Sciences

Zethelius, Björn (author): Uppsala universitet,Geriatrik

Vasan, Ramachandran S (author)

Flyvbjerg, Allan (author)

Frystyk, Jan (author)

Berne, Christian (author): Uppsala universitet,Institutionen för medicinska vetenskaper

Hänni, Arvo (author): Uppsala universitet,Geriatrik

Lind, Lars (author): Uppsala universitet,Institutionen för medicinska vetenskaper

Sundström, Johan (author): Uppsala universitet,Institutionen för medicinska vetenskaper

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The Endocrine Society, 2009
2009
English.
In: Journal of Clinical Endocrinology and Metabolism. - : The Endocrine Society. - 0021-972X .- 1945-7197. ; 94:3, s. 953-957

Related links:: https://academic.oup...; show more...; https://urn.kb.se/re...; https://doi.org/10.1...; http://kipublication...; https://urn.kb.se/re...; show less...

Journal article (peer-reviewed)

Abstract Subject headings

CONTEXT: Skeletal muscle morphology and function are strongly associated with insulin sensitivity. OBJECTIVE: The objective of the study was to test the hypothesis that circulating adiponectin is associated with skeletal muscle morphology and that adiponectin mediates the relation of muscle morphology to insulin sensitivity. DESIGN, SETTINGS, AND PARTICIPANTS: This was a cross-sectional investigation of 461 men aged 71 yr, participants of the community-based Uppsala Longitudinal Study of Adult Men study. MAIN OUTCOME MEASURES: Measures included serum adiponectin, insulin sensitivity measured with euglycemic insulin clamp technique, and capillary density and muscle fiber composition determined from vastus lateralis muscle biopsies. RESULTS: In multivariable linear regression models (adjusting for age, physical activity, fasting glucose, and pharmacological treatment for diabetes), serum adiponectin levels rose with increasing capillary density (beta, 0.30 per 50 capillaries per square millimeter increase; P = 0.041) and higher proportion of type I muscle fibers (beta, 0.27 per 10% increase; P = 0.036) but declined with a higher proportion of type IIb fibers (beta, -0.39 per 10% increase; P = 0.014). Using bootstrap methods to examine the potential role of adiponectin in associations between muscle morphology and insulin sensitivity and the associations of capillary density (beta difference, 0.041; 95% confidence interval 0.001, 0.085) and proportion of type IIb muscle fibers (beta difference, -0.053; 95% confidence interval -0.107, -0.002) with insulin sensitivity were significantly attenuated when adiponectin was included in the models. CONCLUSIONS: Circulating adiponectin concentrations were higher with increasing skeletal muscle capillary density and in individuals with higher proportion of slow oxidative muscle fibers. Furthermore, our results indicate that adiponectin could be a partial mediator of the relations between skeletal muscle morphology and insulin sensitivity.

Subject headings

MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin (hsv//swe)
MEDICAL AND HEALTH SCIENCES -- Clinical Medicine (hsv//eng)

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MEDICINE
MEDICIN
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By the author/editor: Ingelsson, Erik; Ärnlöv, Johan; Zethelius, Björn; Vasan, Ramachand ...; Flyvbjerg, Allan; Frystyk, Jan; show more...; Berne, Christian; Hänni, Arvo; Lind, Lars; Sundström, Johan; show less...

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MEDICAL AND HEALTH SCIENCES: MEDICAL AND HEAL ...; and Clinical Medicin ...

Articles in the publication: Journal of Clini ...

By the university: Uppsala University; Karolinska Institutet; Högskolan Dalarna

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