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Sökning: id:"swepub:oai:DiVA.org:uu-103797" > A genecentric Human...

LIBRIS Formathandbok  (Information om MARC21)
FältnamnIndikatorerMetadata
00004947naa a2200577 4500
001oai:DiVA.org:uu-103797
003SwePub
008090520s2008 | |||||||||||000 ||eng|
009oai:DiVA.org:kth-9745
0247 a https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-1037972 URI
0247 a https://doi.org/10.1074/mcp.R800013-MCP2002 DOI
0247 a https://urn.kb.se/resolve?urn=urn:nbn:se:kth:diva-97452 URI
040 a (SwePub)uud (SwePub)kth
041 a engb eng
042 9 SwePub
072 7a ref2 swepub-contenttype
072 7a for2 swepub-publicationtype
1001 a Berglund, Lisau KTH,Proteomik4 aut0 (Swepub:kth)u1cyxqho
2451 0a A genecentric Human Protein Atlas for expression profiles based on antibodies
264 1c 2008
338 a print2 rdacarrier
500 a QC 20100708
520 a An attractive path forward in proteomics is to experimentally annotate the human protein complement of the genome in a genecentric manner. Using antibodies, it might be possible to design protein-specific probes for a representative protein from every protein-coding gene and to subsequently use the antibodies for systematical analysis of cellular distribution and subcellular localization of proteins in normal and disease tissues. A new version (4.0) of the Human Protein Atlas has been developed in a genecentric manner with the inclusion of all human genes and splice variants predicted from genome efforts together with a visualization of each protein with characteristics such as predicted membrane regions, signal peptide, and protein domains and new plots showing the uniqueness (sequence similarity) of every fraction of each protein toward all other human proteins. The new version is based on tissue profiles generated from 6120 antibodies with more than five million immunohistochemistry-based images covering 5067 human genes, corresponding to approximately 25% of the human genome. Version 4.0 includes a putative list of members in various protein classes, both functional classes, such as kinases, transcription factors, G-protein-coupled receptors, etc., and project-related classes, such as candidate genes for cancer or cardiovascular diseases. The exact antigen sequence for the internally generated antibodies has also been released together with a visualization of the application-specific validation performed for each antibody, including a protein array assay, Western blot analysis, immunohistochemistry, and, for a large fraction, immunofluorescence-based confocal microscopy. New search functionalities have been added to allow complex queries regarding protein expression profiles, protein classes, and chromosome location. The new version of the protein atlas thus is a resource for many areas of biomedical research, including protein science and biomarker discovery.
650 7a TEKNIK OCH TEKNOLOGIERx Industriell bioteknik0 (SwePub)2092 hsv//swe
650 7a ENGINEERING AND TECHNOLOGYx Industrial Biotechnology0 (SwePub)2092 hsv//eng
653 a MEDICINE
653 a MEDICIN
653 a CANCER TISSUES; PROTEOMICS; RESOURCE; DATABASE; MICROARRAYS; GENERATION; LIBRARIES; PEPTIDES; GENOME
653 a Bioengineering
7001 a Björling, Eriku KTH,Proteomik4 aut0 (Swepub:kth)u15l719e
7001 a Oksvold, Peru KTH,Proteomik4 aut0 (Swepub:kth)u1qey3lv
7001 a Fagerberg, Linnu KTH,Proteomik4 aut0 (Swepub:kth)u1dglfid
7001 a Asplund, Annau Uppsala universitet,Institutionen för genetik och patologi4 aut0 (Swepub:uu)annaaspl
7001 a Al-Khalili Szigyarto, Cristinau KTH,Proteomik4 aut0 (Swepub:kth)u1c02mh9
7001 a Persson, Anjau KTH,Proteomik4 aut0 (Swepub:kth)u1ub8a38
7001 a Ottosson, Jennyu KTH,Proteomik4 aut0 (Swepub:kth)u1lthxtb
7001 a Wernérus, Henriku KTH,Proteomik4 aut0 (Swepub:kth)u1v2ednd
7001 a Nilsson, Peteru KTH,Proteomik4 aut0 (Swepub:kth)u1ws88sk
7001 a Lundberg, Emmau KTH,Proteomik4 aut0 (Swepub:kth)u12bylj1
7001 a Sivertsson, Åsau KTH,Proteomik4 aut0 (Swepub:kth)u195d5b0
7001 a Navani, Sanjay4 aut
7001 a Wester, Kennethu Uppsala universitet,Institutionen för genetik och patologi4 aut0 (Swepub:uu)kennwest
7001 a Kampf, Carolineu Uppsala universitet,Institutionen för genetik och patologi4 aut0 (Swepub:uu)carokamp
7001 a Hober, Sophiau KTH,Proteomik4 aut0 (Swepub:kth)u11qqzc1
7001 a Pontén, Fredriku Uppsala universitet,Institutionen för genetik och patologi4 aut0 (Swepub:uu)fredpont
7001 a Uhlén, Mathiasu KTH,Proteomik4 aut0 (Swepub:kth)u1dulvmw
7102 a KTHb Proteomik4 org
7730 t Molecular & Cellular Proteomicsg 7:10, s. 2019-2027q 7:10<2019-2027x 1535-9476x 1535-9484
8564 8u https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-103797
8564 8u https://doi.org/10.1074/mcp.R800013-MCP200
8564 8u https://urn.kb.se/resolve?urn=urn:nbn:se:kth:diva-9745

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