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Neural crest stem cells increase beta cell proliferation and improve islet function in co-transplanted murine pancreatic islets
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- Olerud, Johan (author)
- Uppsala universitet,Institutionen för medicinsk cellbiologi
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- Kanaykina, Nadegda (author)
- Uppsala universitet,Neuroanatomi,Neuroanatomy
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- Vasilovska, Svitlana (author)
- Uppsala universitet,Neuroanatomi,Neuroanatomy
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- (creator_code:org_t)
- 2009-10-13
- 2009
- English.
- In: Diabetologia. - : Springer Science and Business Media LLC. - 0012-186X .- 1432-0428. ; 52:12, s. 2594-2601
- Journal article (peer-reviewed)
Abstract
Subject headings
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- AIMS/HYPOTHESIS: Long-term graft survival after islet transplantation to patientswith type 1 diabetes is insufficient, necessitating the development of newstrategies to enhance transplant viability. Here we investigated whetherco-transplantation of neural crest stem cells (NCSCs) with islets improves islet survival and function in normoglycaemic and diabetic mice. METHODS: Islets alone or together with NCSCs were transplanted under the kidney capsule tonormoglycaemic or alloxan-induced diabetic mice. Grafts were analysed for size,proliferation, apoptosis and insulin release. In diabetic recipients bloodglucose levels were examined before and after graft removal. RESULTS: In mixedtransplants NCSCs actively migrated and extensively associated withco-transplanted pancreatic islets. Proliferation of beta cells was markedlyincreased and transplants displayed improved insulin release in normoglycaemicmice compared with those receiving islet-alone transplants. Mixed grafts survivedsuccessfully and partially restored normoglycaemia in alloxan-induced diabeticmice. CONCLUSIONS/INTERPRETATION: Co-grafting of NCSCs with pancreatic isletsimproved insulin release in mixed transplants and enhanced beta cellproliferation, resulting in increased beta cell mass. This co-transplantationmodel offers an opportunity to restore neural-islet interactions and improveislet functions after transplantation.
Keyword
- Diabetes
- Islets of Langerhans
- Neural stem cells
- Transplantation
- Trophic factor
- MEDICINE
- MEDICIN
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- ref (subject category)
- art (subject category)
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- Diabetologia
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