Moderate hypothermia induces a preferential increase in pancreatic islet blood flow in anesthetized rats

Hultström, Michael (author): Uppsala universitet,Institutionen för medicinsk cellbiologi

Jansson, Leif (author): Uppsala universitet,Institutionen för medicinsk cellbiologi

Bodin, Birgitta (author): Uppsala universitet,Institutionen för medicinsk cellbiologi

Källskog, Örjan (author): Uppsala universitet,Institutionen för medicinsk cellbiologi

(creator_code:org_t)

American Physiological Society, 2007
2007
English.
In: American Journal of Physiology. Regulatory Integrative and Comparative Physiology. - : American Physiological Society. - 0363-6119 .- 1522-1490. ; 293:3, s. R1438-R1443

Related links:: https://urn.kb.se/re...; show more...; https://doi.org/10.1...; show less...

Abstract Subject headings

The aim of the study was to characterize the effects of induced moderate hypothermia on splanchnic blood flow, with particular reference to that of the pancreas and the islets of Langerhans. We also investigated how interference with the autonomic nervous system at different levels influenced the blood perfusion during hypothermia. For this purpose, hypothermia (body temperature of 28°C) was induced by external cooling, whereas normothermic (37.5°C) anesthetized Sprague-Dawley rats were used as controls. Some rats were pretreated with either propranolol, yohimbine, atropine, hexamethonium, or a bilateral abdominal vagotomy. Our findings suggest that moderate hypothermia elicits complex, organ-specific circulatory changes, with increased perfusion noted in the pylorus, as well as the whole pancreas and the pancreatic islets. The pancreatic islets maintain their high blood perfusion through mechanisms involving both sympathetic and parasympathetic mediators, whereas the increased pyloric blood flow is mediated through parasympathetic mechanisms. Renal blood flow was decreased, and this can be prevented by ganglionic blockade and is also influenced by β-adrenoceptors.

By the author/editor: Hultström, Micha ...; Jansson, Leif; Bodin, Birgitta; Källskog, Örjan

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