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The stability of AQT processing speed, ADAS-Cog and MMSE during acetylcholinesterase inhibitor treatment in Alzheimer's disease
- Wiig, E H (author)
-
- Annas, P (author)
- Karolinska Institutet
- Basun, H (author)
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- Zetterberg, H (author)
- Blennow, K (author)
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- (creator_code:org_t)
- Hindawi Limited, 2010
- 2010
- English.
- In: Acta Neurologica Scandinavica. - : Hindawi Limited. - 0001-6314 .- 1600-0404. ; 121:3, s. 186-193
- Journal article (peer-reviewed)
Abstract
Subject headings
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- OBJECTIVES: To explore the longitudinal stability of measures of cognition during treatment with acetylcholinesterase inhibitors (AchEI) in patients with Alzheimer's disease (AD). MATERIALS AND METHODS: Cognitive status was measured in a cohort of 60 patients at 6 months after initiation of treatment with AchEI (baseline) and after an additional 6 months of treatment (endpoint). A Quick Test of Cognitive Speed (AQT), Alzheimer's Disease Assessment Scale-Cognitive Subscale (ADAS-Cog), and MMSE were administered concurrently. RESULTS: Correlations (rho) between age and AQT processing speed were non-significant, but were significant for ADAS-Cog and Mini Mental State Examination (MMSE). AQT and ADAS-Cog means did not differ significantly between baseline and endpoint. There was a small, significant reduction in MMSE point scores. Measures of stability (Spearman's rho) were moderate-to-high for all tests. Means for subgroups did not differ as a function of medication type. CONCLUSIONS: AQT processing speed, ADAS-Cog, and MMSE measures proved stable during the second 6 months of treatment with AChEI.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Neurologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Neurology (hsv//eng)
Keyword
- AQT
- processing speed
- ADAS-Cog
- MMSE
- Alzheimer's disease
- AchEI treatment
- longitudinal stability
- MEDICINE
- MEDICIN
- treatment
- AchEI
- Alzheimer's disease
- MMSE
- ADAS-Cog
- AQT
- processing speed
- longitudinal stability
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- ref (subject category)
- art (subject category)
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- Wiig, E H
- Annas, P
- Basun, H
- Andreasen, N
- Lannfelt, Lars
- Zetterberg, H
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- Blennow, K
- Minthon, Lennart
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- MEDICAL AND HEALTH SCIENCES
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- Uppsala University
- Lund University
- Karolinska Institutet
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