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Shb null allele is inherited with a transmission ratio distortion and causes reduced viability in utero
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- Kriz, Vitezslav (author)
- Uppsala universitet,Institutionen för medicinsk cellbiologi
- Mares, Jaroslav (author)
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- Wentzel, Parri (author)
- Uppsala universitet,Institutionen för medicinsk cellbiologi
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- 2007
- 2007
- English.
- In: Developmental Dynamics. - : Wiley. - 1058-8388 .- 1097-0177. ; 236:9, s. 2485-2492
- Journal article (peer-reviewed)
Abstract
Subject headings
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- SHB is an Src homology 2 domain-containing adapter protein that has been found to be involved in numerous cellular responses. We have generated an Shb knockout mouse. No Shb-/- pups or embryos were obtained on the C57Bl6 background, indicating an early defect as a consequence of Shb- gene inactivation on this genetic background. Breeding heterozygotes for Shb gene inactivation (Shb+/-) on a mixed genetic background (FVB/C57Bl6/129Sv) reveals a distorted transmission ratio of the null allele with reduced numbers of Shb+/+ and Shb-/- animals, but increased number of Shb+/- animals. The Shb- allele is associated with various forms of malformations, explaining the relative reduction in the number of Shb-/- offspring. Shb-/- animals that were born were viable, fertile, and showed no obvious defects. However, Shb+/- female mice ovulated preferentially Shb- oocytes explaining the reduced frequency of Shb+/+ mice. Our study suggests a role of SHB during reproduction and development.
Keyword
- Knockout
- Malformations
- Ovulation
- SHB
- Transmission ratio distortion
- Viability in utero
- MEDICINE
- MEDICIN
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- ref (subject category)
- art (subject category)
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