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Coexistence of passive and carrier-mediated processes in drug transport
- Sugano, Kiyohiko (author)
- Kansy, Manfred (author)
-
- Artursson, Per (author)
- Uppsala universitet,Institutionen för farmaci
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- Avdeef, Alex (author)
- Bendels, Stefanie (author)
- Di, Li (author)
- Ecker, Gerhard F (author)
- Faller, Bernard (author)
- Fischer, Holger (author)
- Gerebtzoff, Grégori (author)
- Senner, Frank (author)
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- (creator_code:org_t)
- Springer Science and Business Media LLC, 2010
- 2010
- English.
- In: Nature reviews. Drug discovery. - : Springer Science and Business Media LLC. - 1474-1776 .- 1474-1784. ; 9:8, s. 597-614
- Journal article (peer-reviewed)
Abstract
Subject headings
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- The permeability of biological membranes is one of the most important determinants of the pharmacokinetic processes of a drug. Although it is often accepted that many drug substances are transported across biological membranes by passive transcellular diffusion, a recent hypothesis speculated that carrier-mediated mechanisms might account for the majority of membrane drug transport processes in biological systems. Based on evidence of the physicochemical characteristics and of in vitro and in vivo findings for marketed drugs, as well as results from real-life discovery and development projects, we present the view that both passive transcellular processes and carrier-mediated processes coexist and contribute to drug transport activities across biological membranes.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Farmaceutiska vetenskaper (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Pharmaceutical Sciences (hsv//eng)
Keyword
- PHARMACY
- FARMACI
Publication and Content Type
- ref (subject category)
- art (subject category)
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- Sugano, Kiyohiko
- Kansy, Manfred
- Artursson, Per
- Avdeef, Alex
- Bendels, Stefani ...
- Di, Li
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- Ecker, Gerhard F
- Faller, Bernard
- Fischer, Holger
- Gerebtzoff, Grég ...
- Lennernäs, Hans
- Senner, Frank
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- About the subject
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- MEDICAL AND HEALTH SCIENCES
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- Uppsala University
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