Serum ferritin and erythrocyte 2,3-DPG during quantitated phlebotomy and iron treatment

Birgegård, GunnarUppsala universitet,Institutionen för medicinska vetenskaper (author)

Serum ferritin and erythrocyte 2,3-DPG levels were followed in 3 healthy males who were phlebotomized to iron depletion and a moderate anaemia. In 2 of the subjects, the expected rise in DPG levels was seen but not in the third, in spite of a Hb concentration of 95 g/1. Serum ferritin levels were found to reflect changes in iron stores, and subnormal serum ferritin indicated depleted iron stores. However, there was no correlation between pre-phlebotomy ferritin levels and calculated iron stores. The conclusion is that no fixed ratio can be established between serum ferritin and iron stores. A single ferritin value within the normal range does not tell how large iron stores a person has. Changes in an individual's iron stores can, however, be detected by repeated ferritin estimations.

Högman, C. (author)
Killander, A. (author)
Levander, H. (author)
Simonsson, B. (author)
Wide, L. (author)
Uppsala universitetInstitutionen för medicinska vetenskaper (creator_code:org_t)

By the author/editor: Birgegård, Gunna ...; Högman, C.; Killander, A.; Levander, H.; Simonsson, B.; Wide, L.

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