id:"swepub:oai:DiVA.org:uu-137253"
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| Fältnamn | Indikatorer | Metadata |
|---|---|---|
| 000 | 02313naa a2200289 4500 | |
| 001 | oai:DiVA.org:uu-137253 | |
| 003 | SwePub | |
| 008 | 101215s2003 | |||||||||||000 ||eng| | |
| 024 | 7 | a https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-1372532 URI |
| 040 | a (SwePub)uu | |
| 041 | a engb eng | |
| 042 | 9 SwePub | |
| 072 | 7 | a ref2 swepub-contenttype |
| 072 | 7 | a art2 swepub-publicationtype |
| 100 | 1 | a Hagberg, A.4 aut |
| 245 | 1 0 | a Beta-globin mRNA increases rapidly during erythropoietin treatment |
| 264 | 1 | c 2003 |
| 338 | a print2 rdacarrier | |
| 520 | a Recombinant human erythropoietin (r-HuEpo) has an important role in the treatment of anaemic patients. Because of the high cost of r-HuEpo treatment, an early indicator of whether a patient is responding to the therapy would be valuable. Although measurement of gene expression is a promising new tool, it has not yet been established in clinical practice. The response pattern of a possible new marker, beta-globin mRNA, is compared with reticulocyte count, levels of haemoglobin, transferrin receptor and ferritin after r-HuEpo treatment. Eight healthy volunteers were stimulated with erythropoietin three times a week for four weeks and compared with five untreated control subjects. Blood samples were collected before each erythropoietin injection. Quantitative measurement of beta-globin mRNA was performed by poly(A) selection onto a manifold plastic support, coated with oligo(dT). The mRNA was reverse transcribed, followed by quantitative analysis using PCR via the 5' nuclease assay. The individuals treated with rHuEpo showed a more distinct increase in beta-globin mRNA levels than all other laboratory measurements. Beta-globin mRNA levels are therefore promising as a marker for the response to treatment with Epo. | |
| 653 | a MEDICINE | |
| 653 | a MEDICIN | |
| 700 | 1 | a Barbany, G.4 aut |
| 700 | 1 | a Landegren, U.4 aut |
| 700 | 1 | a Birgegård, Gunnar,d 1944-u Uppsala universitet,Institutionen för medicinska vetenskaper,Hematologi4 aut |
| 710 | 2 | a Uppsala universitetb Institutionen för medicinska vetenskaper4 org |
| 773 | 0 | t Scandinavian Journal of Clinical and Laboratory Investigationg 63:3, s. 239-245q 63:3<239-245x 0036-5513x 1502-7686 |
| 856 | 4 8 | u https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-137253 |
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