id:"swepub:oai:DiVA.org:uu-137727"
Sökning: id:"swepub:oai:DiVA.org:uu-137727" > Transcapillary exch...
- 1 av 1
- Föregående post
- Nästa post
- Till träfflistan
Transcapillary exchange : role and importance of the interstitial fluid pressure and the extracellular matrix
- Reed, Rolf K. (författare)
-
- Rubin, Kristofer (författare)
- Uppsala universitet,Institutionen för medicinsk biokemi och mikrobiologi
- (creator_code:org_t)
- 2010-05-13
- 2010
- Engelska.
- Ingår i: Cardiovascular Research. - : Oxford University Press (OUP). - 0008-6363 .- 1755-3245. ; 87:2, s. 211-217
- Forskningsöversikt (refereegranskat)
Abstract
Ämnesord
Stäng
- This review will summarize current knowledge on the role of the extracellular matrix (ECM) in general and on the interstitial fluid pressure (P-if) in particular with regard to their importance in transcapillary exchange. The fluid volume in the interstitial space is normally regulated within narrow limits by automatic re-adjustment of the interstitial hydrostatic and colloid osmotic pressures in response to perturbations in capillary filtration and by the lymphatics. Contrary to this commonly accepted view, P-if can become an active force and create a fluid flux across the capillaries in several inflammatory reactions and trauma situations rather than limit the changes occurring. The molecular mechanisms involved in the lowering of P-if include the release of cellular tension exerted on the collagen and microfibril networks in the connective tissue via the collagen-binding beta(1)-integrins, thereby allowing the glycosaminoglycan ground substance, which is normally underhydrated, to expand and take up fluid. Several growth factors and cytokines, including the platelet-derived growth factor BB, are able to reverse a lowering of P-if and restore the normal compaction of the ECM. The magnitude of the lowering of P-if varies with the inflammatory response. In several inflammatory reactions, a lowering of P-if to -5 to -10 mmHg is seen, which will increase capillary filtration by 10-20 times since the normal capillary filtration pressure is usually 0.5-1 mmHg (skin and skeletal muscle). Unless this lowering of P-if is taken into account, the enhanced solute flux resulting from an inflammatory response will be ascribed to an increased capillary permeability.
Nyckelord
- Connective tissue
- beta-Integrin receptors
- Glycosaminoglycans
- Inflammation
- MEDICINE
- MEDICIN
Publikations- och innehållstyp
- ref (ämneskategori)
- for (ämneskategori)
Hitta via bibliotek
- Cardiovascular Research (Sök värdpublikationen i LIBRIS)
Till lärosätets databas
- 1 av 1
- Föregående post
- Nästa post
- Till träfflistan
Hitta mer i SwePub
- Av författaren/redakt...
- Reed, Rolf K.
- Rubin, Kristofer
- Artiklar i publikationen
- Cardiovascular R ...
- Av lärosätet
- Uppsala universitet
Sök utanför SwePub
- Sök vidare i:
- Google Book Search
- Google Scholar
Kungliga biblioteket hanterar dina personuppgifter i enlighet med EU:s dataskyddsförordning (2018), GDPR. Läs mer om hur det funkar här.
Så här hanterar KB dina uppgifter vid användning av denna tjänst.
- Copyright © LIBRIS - Nationella bibliotekssystem
- LIBRIS.kb.se
