id:"swepub:oai:DiVA.org:uu-137727"
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| Fältnamn | Indikatorer | Metadata |
|---|---|---|
| 000 | 03163naa a2200361 4500 | |
| 001 | oai:DiVA.org:uu-137727 | |
| 003 | SwePub | |
| 008 | 101215s2010 | |||||||||||000 ||eng| | |
| 024 | 7 | a https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-1377272 URI |
| 024 | 7 | a https://doi.org/10.1093/cvr/cvq1432 DOI |
| 040 | a (SwePub)uu | |
| 041 | a engb eng | |
| 042 | 9 SwePub | |
| 072 | 7 | a ref2 swepub-contenttype |
| 072 | 7 | a for2 swepub-publicationtype |
| 100 | 1 | a Reed, Rolf K.4 aut |
| 245 | 1 0 | a Transcapillary exchange :b role and importance of the interstitial fluid pressure and the extracellular matrix |
| 264 | c 2010-05-13 | |
| 264 | 1 | b Oxford University Press (OUP),c 2010 |
| 338 | a print2 rdacarrier | |
| 520 | a This review will summarize current knowledge on the role of the extracellular matrix (ECM) in general and on the interstitial fluid pressure (P-if) in particular with regard to their importance in transcapillary exchange. The fluid volume in the interstitial space is normally regulated within narrow limits by automatic re-adjustment of the interstitial hydrostatic and colloid osmotic pressures in response to perturbations in capillary filtration and by the lymphatics. Contrary to this commonly accepted view, P-if can become an active force and create a fluid flux across the capillaries in several inflammatory reactions and trauma situations rather than limit the changes occurring. The molecular mechanisms involved in the lowering of P-if include the release of cellular tension exerted on the collagen and microfibril networks in the connective tissue via the collagen-binding beta(1)-integrins, thereby allowing the glycosaminoglycan ground substance, which is normally underhydrated, to expand and take up fluid. Several growth factors and cytokines, including the platelet-derived growth factor BB, are able to reverse a lowering of P-if and restore the normal compaction of the ECM. The magnitude of the lowering of P-if varies with the inflammatory response. In several inflammatory reactions, a lowering of P-if to -5 to -10 mmHg is seen, which will increase capillary filtration by 10-20 times since the normal capillary filtration pressure is usually 0.5-1 mmHg (skin and skeletal muscle). Unless this lowering of P-if is taken into account, the enhanced solute flux resulting from an inflammatory response will be ascribed to an increased capillary permeability. | |
| 653 | a Connective tissue | |
| 653 | a beta-Integrin receptors | |
| 653 | a Glycosaminoglycans | |
| 653 | a Inflammation | |
| 653 | a MEDICINE | |
| 653 | a MEDICIN | |
| 700 | 1 | a Rubin, Kristoferu Uppsala universitet,Institutionen för medicinsk biokemi och mikrobiologi4 aut0 (Swepub:uu)krisrubi |
| 710 | 2 | a Uppsala universitetb Institutionen för medicinsk biokemi och mikrobiologi4 org |
| 773 | 0 | t Cardiovascular Researchd : Oxford University Press (OUP)g 87:2, s. 211-217q 87:2<211-217x 0008-6363x 1755-3245 |
| 856 | 4 | u https://academic.oup.com/cardiovascres/article-pdf/87/2/211/17877807/cvq143.pdf |
| 856 | 4 8 | u https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-137727 |
| 856 | 4 8 | u https://doi.org/10.1093/cvr/cvq143 |
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