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Acquired aplastic a...
Acquired aplastic anaemia in seven children with severe hepatitis with or without liver failure
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- Honkaniemi, Emma (author)
- Karolinska Institutet
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- Gustafsson, Britt (author)
- Karolinska Institutet
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- Fischler, Björn (author)
- Karolinska Institutet
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- Nemeth, Antal (author)
- Karolinska Institutet
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- Frost, Britt-Marie (author)
- Uppsala universitet,Pediatrik
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- Papadogiannakis, Nikos (author)
- Karolinska Institutet
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- Winiarski, Jacek (author)
- Karolinska Institutet
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(creator_code:org_t)
- Wiley, 2007
- 2007
- English.
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In: Acta Paediatrica. - : Wiley. - 0803-5253 .- 1651-2227. ; 96:11, s. 1660-1664
- Related links:
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https://urn.kb.se/re...
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https://doi.org/10.1...
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http://kipublication...
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Abstract
Subject headings
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- Aim: Aplastic anaemia following hepatitis may develop in as many as 1 of 3 patients with non-A, non-B and non-C hepatitis. Several causative factors have been discussed, such as viral infections and autoimmunity. Here we describe the natural history of this condition in 7 children and investigate possible hepatitis-causing agents. Methods: We reviewed the medical records, bone marrow and liver biopsies of 7 children with severe hepatitis, with or without liver failure, who subsequently had developed aplastic anaemia. Results: The median time from onset of hepatic symptoms until diagnosed onset of aplasia was 54 days. No associated viral infections could be identified. On liver biopsy, a majority had lobular inflammation but lacked signs of autoimmune hepatitis, findings compatible with a viral aetiology. Three of 6 children had low reticulocyte counts already at onset of hepatitis. All, but one patient is alive at median follow-up of 8 years. Conclusion: The unknown pathogenetic mechanism appears to target liver and bone marrow simultaneously, because half of the children concomitantly had low reticulocyte counts and severe liver failure.
Keyword
- aplastic anaemia
- hepatitis
- liver failure
- virus infection
- MEDICINE
- MEDICIN
Publication and Content Type
- ref (subject category)
- art (subject category)
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