Search: id:"swepub:oai:DiVA.org:uu-152265" >
Both CD4(+) FoxP3(+...
Both CD4(+) FoxP3(+) and CD4(+) FoxP3(-) T cells from patients with B-cell malignancy express cytolytic markers and kill autologous leukaemic B cells in vitro.
-
- Lindqvist, Camilla (author)
- Uppsala universitet,Klinisk immunologi,Science for Life Laboratory, SciLifeLab
-
- Christiansson, Lisa (author)
- Uppsala universitet,Klinisk immunologi,Science for Life Laboratory, SciLifeLab
-
- Thörn, Ingrid (author)
- Uppsala universitet,Molekylär och morfologisk patologi,Science for Life Laboratory, SciLifeLab
-
show more...
-
- Mangsbo, Sara (author)
- Uppsala universitet,Klinisk immunologi,Science for Life Laboratory, SciLifeLab
-
- Paul-Wetterberg, Gabriella (author)
- Uppsala universitet,Klinisk immunologi,Science for Life Laboratory, SciLifeLab
-
- Sundström, Christer (author)
- Uppsala universitet,Molekylär och morfologisk patologi,Science for Life Laboratory, SciLifeLab
-
- Tötterman, Thomas (author)
- Uppsala universitet,Klinisk immunologi,Science for Life Laboratory, SciLifeLab
-
- Simonsson, Bengt (author)
- Uppsala universitet,Medicin,Hematologi
-
- Enblad, Gunilla (author)
- Uppsala universitet,Enheten för onkologi
-
- Frisk, Per, 1966- (author)
- Uppsala universitet,Enheten för onkologi
-
- Olsson Strömberg, Ulla (author)
- Uppsala universitet,Medicin,Hematologi
-
- Loskog, Angelica (author)
- Uppsala universitet,Klinisk immunologi,Science for Life Laboratory, SciLifeLab
-
show less...
-
(creator_code:org_t)
- 2011-04-05
- 2011
- English.
-
In: Immunology. - : Wiley. - 0019-2805 .- 1365-2567. ; 133:3, s. 296-306
- Related links:
-
https://www.ncbi.nlm...
-
show more...
-
https://urn.kb.se/re...
-
https://doi.org/10.1...
-
show less...
Abstract
Subject headings
Close
- P>Cytotoxic CD4+ T cells have been found in patients with chronic lymphocytic leukaemia (CLL) and seem to be involved in the regulation of malignant B cells. The CD4+ T regulatory cells (Tregs) can regulate various immune cells, including B cells, by inducing their apoptosis. Hence, different subgroups of CD4+ T cells may be involved in the regulation of malignant B cells. In this study, the cytotoxic phenotype and function of various CD4+ T-cell subgroups were investigated in patients with B-cell malignancies. Peripheral blood was collected from patients with CLL, various B-cell lymphomas, healthy adult donors, children with precursor B-cell acute lymphoblastic leukaemia (pre-B ALL) and from healthy children. CD4+ T cells (CD3+ CD4+ FoxP3-), Tregs (CD3+ CD4+ CD127low FoxP3+) and CD127high FoxP3+ T cells (CD3+ CD4+ CD127high FoxP3+) were analysed for their expression of the cytolytic markers CD107a and Fas ligand. Patients with CLL had increased CD107a expression on all tested T-cell subgroups compared with healthy donors. Similar results were found in patients with B-cell lymphomas whereas the CD107a expression in children with pre-B ALL was no different from that in healthy controls. Fas ligand expression was similar between patient cells and cells of healthy donors. CD4+ T cells and Tregs from patients with CLL and healthy donors were subsequently purified and cultured in vitro with autologous B cells. Both subgroups lysed B cells and killing was confirmed by granzyme ELISAs. In conclusion, cytotoxic populations of CD4+ T cells, including Tregs, are present in patients with B-cell malignancy and may be an important factor in immune-related disease control.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Immunologi inom det medicinska området (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Immunology in the medical area (hsv//eng)
Keyword
- B-cell lymphoma
- CD107a
- chronic lymphocytic leukaemia
- Fas ligand
- FoxP3
- granzyme
- precursor B-cell acute lymphoblastic leukaemia
- Tumour immunology
- Tumörimmunologi
- Immunologi
- Immunology
Publication and Content Type
- ref (subject category)
- art (subject category)
Find in a library
-
Immunology
(Search for host publication in LIBRIS)
To the university's database
- By the author/editor
-
Lindqvist, Camil ...
-
Christiansson, L ...
-
Thörn, Ingrid
-
Mangsbo, Sara
-
Paul-Wetterberg, ...
-
Sundström, Chris ...
-
show more...
-
Tötterman, Thoma ...
-
Simonsson, Bengt
-
Enblad, Gunilla
-
Frisk, Per, 1966 ...
-
Olsson Strömberg ...
-
Loskog, Angelica
-
show less...
- About the subject
-
- MEDICAL AND HEALTH SCIENCES
-
MEDICAL AND HEAL ...
-
and Basic Medicine
-
and Immunology in th ...
- Articles in the publication
-
Immunology
- By the university
-
Uppsala University