id:"swepub:oai:DiVA.org:uu-153110"
Search: id:"swepub:oai:DiVA.org:uu-153110" > FOXP3 and survival ...
- 1 of 1
- Previous record
- Next record
- To hitlist
FOXP3 and survival in urinary bladder cancer
-
- Winerdal, Malin E (author)
- Karolinska Institutet
-
- Marits, Per (author)
- Karolinska Institutet
- Winerdal, Max (author)
- show more...
- Selling, Katarina (author)
- show less...
- (creator_code:org_t)
- 2011
- 2011
- English.
- In: BJU International. - 1464-4096 .- 1464-410X. ; 108:10, s. 1672-1678
- Journal article (peer-reviewed)
Abstract
Subject headings
Close
- OBJECTIVE:To investigate the possible impact of FOXP3 expression in T-cells, as well as in tumour cells, on long-term survival in patients with urinary bladder cancer (UBC) invading muscle.PATIENTS AND METHODS:In a retrospective study, tumour specimens from 37 patients cystectomized for T1-T4 UBC during 1999-2002 at the Karolinska University Hospital were examined by immunohistochemistry for tumour expression and/or infiltration of immune cells expressing FOXP3 as well as CD3. The results obtained were correlated with clinicopathological parameters, where the primary and secondary outcomes investigated were overall survival and progression-free survival, respectively.RESULTS:Infiltration of CD3(+) and FOXP3(+) lymphocytes (≥3 cells per high-power field) were both correlated with better survival, and this relationship persisted throughout the whole study period (all P < 0.05). Patients with FOXP3(+) tumour cells had decreased long-term survival compared to those patients with FOXP3(-) tumours (P < 0.05). Despite a limited amount of patient material, the results of the present study indicate that FOXP3 expression, in both lymphocytes and tumour cells, is an important prognostic factor in UBC.CONCLUSIONS:FOXP3 expression in UBC cells is associated with decreased long-term survival and thus may be a novel negative prognostic factor in UBC invading muscle. By contrast, the presence of FOXP3(+) tumour-infiltrating lymphocytes was correlated with a positive prognosis. Because FOXP3 is up-regulated upon activation in human T-cells, FOXP3 may serve more as an activation marker than as a regulatory T-cell indicator in this case. These results support the need for larger prospective studies aiming to confirm the results obtained and to examine the underlying mechanisms in detail.
Keyword
- Urology and andrology
- Urologi och andrologi
- Urologi
- Urology
- Pathology
- Patologi
Publication and Content Type
- ref (subject category)
- art (subject category)
Find in a library
- BJU International (Search for host publication in LIBRIS)
To the university's database
- 1 of 1
- Previous record
- Next record
- To hitlist
Find more in SwePub
- By the author/editor
- Winerdal, Malin ...
- Marits, Per
- Winerdal, Max
- Hasan, Mudhar
- Rosenblatt, Robe ...
- Tolf, Anna
- show more...
- Selling, Katarin ...
- Sherif, Amir
- Winqvist, Ola
- show less...
- Articles in the publication
- BJU Internationa ...
- By the university
- Uppsala University
- Karolinska Institutet
Search outside SwePub
- Extend your search to:
- Google Book Search
- Google Scholar
Kungliga biblioteket hanterar dina personuppgifter i enlighet med EU:s dataskyddsförordning (2018), GDPR. Läs mer om hur det funkar här.
Så här hanterar KB dina uppgifter vid användning av denna tjänst.
- Copyright © LIBRIS - National Library Systems
- LIBRIS.kb.se
