id:"swepub:oai:DiVA.org:uu-161359"
Sökning: id:"swepub:oai:DiVA.org:uu-161359" > Incidence and clini...
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| Fältnamn | Indikatorer | Metadata |
|---|---|---|
| 000 | 03253naa a2200337 4500 | |
| 001 | oai:DiVA.org:uu-161359 | |
| 003 | SwePub | |
| 008 | 111111s2006 | |||||||||||000 ||eng| | |
| 024 | 7 | a https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-1613592 URI |
| 024 | 7 | a https://doi.org/10.1111/j.1600-0609.2005.00621.x2 DOI |
| 040 | a (SwePub)uu | |
| 041 | a engb eng | |
| 042 | 9 SwePub | |
| 072 | 7 | a ref2 swepub-contenttype |
| 072 | 7 | a art2 swepub-publicationtype |
| 100 | 1 | a Juhl, David4 aut |
| 245 | 1 0 | a Incidence and clinical significance of anti-PF4/heparin antibodies of the IgG, IgM, and IgA class in 755 consecutive patient samples referred for diagnostic testing for heparin-induced thrombocytopenia. |
| 264 | 1 | b Wiley,c 2006 |
| 338 | a print2 rdacarrier | |
| 520 | a BACKGROUND: Heparin-induced thrombocytopenia (HIT) is usually caused by anti-platelet factor 4 (PF4)/heparin antibodies, leading to intravascular platelet activation. These antibodies can be detected by PF4/polyanion antigen assays or platelet activation assays. While antigen assays are very sensitive and recognize immunoglobulin (Ig)G, IgA, and IgM antibodies, the role of IgM and IgA HIT-antibodies is debated. Platelet activation assays recognize IgG and are more specific for clinical HIT. METHODS: We analyzed sera from 755 consecutive patients referred for diagnostic testing for HIT using a PF4/heparin enzyme-linked immunosorbent assay (ELISA) for IgG, IgA, and IgM and by the heparin-induced platelet activation (HIPA) test. Clinical information was provided by the treating physicians. RESULTS: A total of 108 of 755 (14.3%) patients tested positive, 105 (13.9%) in the PF4/heparin IgG/A/M ELISA [28 (26.7%) only for IgM/A]; 53 (7.0%) sera were positive in the HIPA, of those 50 tested also positive in the ELISA. In 77 patients sufficient clinical information was provided. Available clinical information for 17 of the 28 patients who had only IgM and/or IgA detected showed plausible alternative (non-HIT) explanations in four of seven who had thromboembolic complications and in nine of 10 who had isolated HIT. CONCLUSION: Detection of IgG, IgM and IgA class antibodies by PF4/heparin ELISA yields a positive test result about twice as often as does a platelet activation assay, with only a minority of the additional patients detected likely having HIT. Thus, there is a potential for considerable over-diagnosis of HIT by laboratories that utilize only an ELISA for diagnostic testing. | |
| 650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicin0 (SwePub)3022 hsv//swe |
| 650 | 7 | a MEDICAL AND HEALTH SCIENCESx Clinical Medicine0 (SwePub)3022 hsv//eng |
| 700 | 1 | a Eichler, Petra4 aut |
| 700 | 1 | a Lubenow, Norbertu Department of Transfusion Medicine, Greifswald University, Germany4 aut0 (Swepub:uu)norlu522 |
| 700 | 1 | a Strobel, Ulrike4 aut |
| 700 | 1 | a Wessel, Antje4 aut |
| 700 | 1 | a Greinacher, Andreas4 aut |
| 710 | 2 | a Department of Transfusion Medicine, Greifswald University, Germany4 org |
| 773 | 0 | t European Journal of Haematologyd : Wileyg 76:5, s. 420-6q 76:5<420-6x 0902-4441x 1600-0609 |
| 856 | 4 8 | u https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-161359 |
| 856 | 4 8 | u https://doi.org/10.1111/j.1600-0609.2005.00621.x |
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