id:"swepub:oai:DiVA.org:uu-169342"
Sökning: id:"swepub:oai:DiVA.org:uu-169342" > High dose ursodeoxy...
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| Fältnamn | Indikatorer | Metadata |
|---|---|---|
| 000 | 04380naa a2200565 4500 | |
| 001 | oai:DiVA.org:uu-169342 | |
| 003 | SwePub | |
| 008 | 120228s2012 | |||||||||||000 ||eng| | |
| 009 | oai:lup.lub.lu.se:0f29839c-e4ad-4ace-83ff-1422806d66a0 | |
| 009 | oai:prod.swepub.kib.ki.se:123969517 | |
| 009 | oai:DiVA.org:umu-52644 | |
| 024 | 7 | a https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-1693422 URI |
| 024 | 7 | a https://doi.org/10.1111/j.1365-2036.2011.04966.x2 DOI |
| 024 | 7 | a https://lup.lub.lu.se/record/24162502 URI |
| 024 | 7 | a http://kipublications.ki.se/Default.aspx?queryparsed=id:1239695172 URI |
| 024 | 7 | a https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-526442 URI |
| 040 | a (SwePub)uud (SwePub)lud (SwePub)kid (SwePub)umu | |
| 041 | a engb eng | |
| 042 | 9 SwePub | |
| 072 | 7 | a ref2 swepub-contenttype |
| 072 | 7 | a art2 swepub-publicationtype |
| 100 | 1 | a Lindstrom, L.u Karolinska Institutet4 aut |
| 245 | 1 0 | a High dose ursodeoxycholic acid in primary sclerosing cholangitis does not prevent colorectal neoplasia |
| 264 | c 2012-01-05 | |
| 264 | 1 | a Malden :b Wiley,c 2012 |
| 338 | a print2 rdacarrier | |
| 520 | a Background Patients with primary sclerosing cholangitis (PSC) and inflammatory bowel disease (IBD) have a high risk of developing colorectal cancer and dysplasia. Ursodeoxycholic acid (UDCA) has been suggested to have chemopreventive effects on the development of colorectal cancer and dysplasia but long-term data and larger trials are lacking. Aim To evaluate the effect of high dose (17-23 mg/kg/day) UDCA on colorectal neoplasia in a cohort of patients with PSC and IBD. Methods From our previous 5-year randomised controlled trial of UDCA vs. placebo in PSC, we performed a follow-up of 98 patients with concomitant IBD from entry of the trial 1996-1997 until 2009 for development of colorectal cancer or dysplasia. Results The total follow-up time was 760 person-years. Dysplasia/cancer-free survival was compared between placebo-(n = 50) and UDCA-treated (n = 48) patients. There was a similar frequency of dysplasia or cancer after 5 years between patients originally assigned to UDCA or placebo (13% vs. 16%) and no difference in dysplasia/cancer-free survival (P = 0.46, log rank test). At the end of 2009 no difference in cancer-free survival was detected, 30% of the placebo patients compared with 27% of UDCA patients had developed colorectal cancer or dysplasia. Conclusions Long-term high dose ursodeoxycholic acid does not prevent colorectal cancer or dysplasia in patients with primary sclerosing cholangitis-associated inflammatory bowel disease. | |
| 650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Gastroenterologi0 (SwePub)302132 hsv//swe |
| 650 | 7 | a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Gastroenterology and Hepatology0 (SwePub)302132 hsv//eng |
| 700 | 1 | a Boberg, K. M.4 aut |
| 700 | 1 | a Wikman, O.4 aut |
| 700 | 1 | a Friis-Liby, I.4 aut |
| 700 | 1 | a Hultcrantz, R.u Karolinska Institutet4 aut |
| 700 | 1 | a Prytz, Hanneu Lund University,Lunds universitet,Medicin, Lund,Sektion II,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Medicine, Lund,Section II,Department of Clinical Sciences, Lund,Faculty of Medicine4 aut0 (Swepub:lu)med-hpr |
| 700 | 1 | a Sandberg-Gertzen, H.4 aut |
| 700 | 1 | a Sangfelt, Peru Uppsala universitet,Institutionen för medicinska vetenskaper4 aut0 (Swepub:uu)persangf |
| 700 | 1 | a Rydning, A.4 aut |
| 700 | 1 | a Folvik, G.4 aut |
| 700 | 1 | a Gangsoy-Kristiansen, M.4 aut |
| 700 | 1 | a Danielsson, Åkeu Umeå universitet,Medicin4 aut0 (Swepub:umu)akda0001 |
| 700 | 1 | a Bergquist, Annikau Karolinska Institutet4 aut |
| 710 | 2 | a Karolinska Institutetb Medicin, Lund4 org |
| 773 | 0 | t Alimentary Pharmacology and Therapeuticsd Malden : Wileyg 35:4, s. 451-457q 35:4<451-457x 0269-2813x 1365-2036 |
| 856 | 4 | u https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/j.1365-2036.2011.04966.x |
| 856 | 4 | u http://dx.doi.org/10.1111/j.1365-2036.2011.04966.xy FULLTEXT |
| 856 | 4 8 | u https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-169342 |
| 856 | 4 8 | u https://doi.org/10.1111/j.1365-2036.2011.04966.x |
| 856 | 4 8 | u https://lup.lub.lu.se/record/2416250 |
| 856 | 4 8 | u http://kipublications.ki.se/Default.aspx?queryparsed=id:123969517 |
| 856 | 4 8 | u https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-52644 |
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