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Ticke-borne encephalitis is associated with low levels of interleukin-10 in cerebrospinal fluid
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- Günther, Göran (author)
- Uppsala universitet,Infektionssjukdomar
- Haglund, Mats (author)
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- Lindquist, Lars (author)
- Karolinska Institutet
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- Forsgren, Marianne (author)
- Andersson, Birger (author)
- Sköldenberg, Birgit (author)
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- (creator_code:org_t)
- 2011-02-10
- 2011
- English.
- In: Infection Ecology & Epidemiology. - : Informa UK Limited. - 2000-8686. ; 1, s. 6029-
- Journal article (peer-reviewed)
Abstract
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- Tick-borne encephalitis (TBE) is associated with higher morbidity and induces a stronger intrathecal immune activation than most other viral induced meningo-encephalitis. The aim of this study was to investigate cytokine concentrations in cerebrospinal fluid (CSF) and serum in relation to aetiology and clinical course. Cytokines were analysed by Enzyme-linked Immuno Assay (ELISA) from 44 patients with TBE and from 36 patients with aseptic meningo-encephalitis of other aetiology (non-TBE). Significantly increased CSF levels of Interferon-γ (IFN-γ), Interleukin-10 (IL-10), Interleukin-6 (IL-6), Interleukin-1 receptor antagonist (IL- 1ra), and soluble CD8 receptor (sCD8) were detected in both cohorts. Tumour necrosis factor-α (TNF-α showed low levels or was not detected in CSF in any group in the acute stage. However, the CSF levels of IL- 10 were significantly lower in TBE than in non-TBE cases 06 days after onset of encephalitis. The TBE patients with encephalitis had significantly lower IL-10 CSF levels later in the clinical course (day 718) than TBE patients with meningeal disease. Increased IFN-γ production, but low IL-10 secretion, may be of pathophysiological significance in TBE.
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