id:"swepub:oai:DiVA.org:uu-175309"
Sökning: id:"swepub:oai:DiVA.org:uu-175309" > GABA-A Channel Subu...
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| Fältnamn | Indikatorer | Metadata |
|---|---|---|
| 000 | 04457naa a2200493 4500 | |
| 001 | oai:DiVA.org:uu-175309 | |
| 003 | SwePub | |
| 008 | 120605s2012 | |||||||||||000 ||eng| | |
| 009 | oai:prod.swepub.kib.ki.se:124815072 | |
| 024 | 7 | a https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-1753092 URI |
| 024 | 7 | a https://doi.org/10.1371/journal.pone.00370412 DOI |
| 024 | 7 | a http://kipublications.ki.se/Default.aspx?queryparsed=id:1248150722 URI |
| 040 | a (SwePub)uud (SwePub)ki | |
| 041 | a engb eng | |
| 042 | 9 SwePub | |
| 072 | 7 | a ref2 swepub-contenttype |
| 072 | 7 | a art2 swepub-publicationtype |
| 100 | 1 | a Smits, Anjau Uppsala universitet,Neurologi4 aut0 (Swepub:uu)anjasmit |
| 245 | 1 0 | a GABA-A Channel Subunit Expression in Human Glioma Correlates with Tumor Histology and Clinical Outcome |
| 264 | c 2012-05-17 | |
| 264 | 1 | b Public Library of Science (PLoS),c 2012 |
| 338 | a electronic2 rdacarrier | |
| 520 | a GABA (γ-aminobutyric acid) is the main inhibitory neurotransmitter in the CNS and is present in high concentrations in presynaptic terminals of neuronal cells. More recently, GABA has been ascribed a more widespread role in the control of cell proliferation during development where low concentrations of extrasynaptic GABA induce a tonic activation of GABA receptors. The GABA-A receptor consists of a ligand-gated chloride channel, formed by five subunits that are selected from 19 different subunit isoforms. The functional and pharmacological properties of the GABA-A channels are dictated by their subunit composition. Here we used qRT-PCR to compare mRNA levels of all 19 GABA-A channel subunits in samples of human glioma (n = 29) and peri-tumoral tissue (n = 5). All subunits except the ρ1 and ρ3 subunit were consistently detected. Lowest mRNA levels were found in glioblastoma compared to gliomas of lower malignancy, except for the θ subunit. The expression and cellular distribution of the α1, γ1, ρ2 and θ subunit proteins was investigated by immunohistochemistry on tissue microarrays containing 87 gliomas grade II. We found a strong co-expression of ρ2 and θ subunits in both astrocytomas (r = 0.86, p<0.0001) and oligodendroglial tumors (r = 0.66, p<0.0001). Kaplan-Meier analysis and Cox proportional hazards modeling to estimate the impact of GABA-A channel subunit expression on survival identified the ρ2 subunit (p = 0.043) but not the θ subunit (p = 0.64) as an independent predictor of improved survival in astrocytomas, together with established prognostic factors. Our data give support for the presence of distinct GABA-A channel subtypes in gliomas and provide the first link between specific composition of the A-channel and patient survival. | |
| 650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Neurologi0 (SwePub)302072 hsv//swe |
| 650 | 7 | a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Neurology0 (SwePub)302072 hsv//eng |
| 653 | a Neurology | |
| 653 | a Neurologi | |
| 700 | 1 | a Jin, Zheu Uppsala universitet,Fysiologi4 aut0 (Swepub:uu)zheji315 |
| 700 | 1 | a Elsir, Tamadoru Uppsala universitet,Neurologi4 aut0 (Swepub:uu)elsta774 |
| 700 | 1 | a Pedder, Hugou Uppsala universitet,Neurologi4 aut |
| 700 | 1 | a Nistér, Monicau Karolinska Institutet4 aut |
| 700 | 1 | a Alafuzoff, Irinau Uppsala universitet,Molekylär och morfologisk patologi4 aut0 (Swepub:uu)irial548 |
| 700 | 1 | a Dimberg, Annau Uppsala universitet,Cancer och vaskulärbiologi4 aut0 (Swepub:uu)annadimb |
| 700 | 1 | a Edqvist, Per-Henriku Uppsala universitet,Molekylär och morfologisk patologi4 aut0 (Swepub:uu)peedq227 |
| 700 | 1 | a Pontén, Fredriku Uppsala universitet,Molekylär och morfologisk patologi4 aut0 (Swepub:uu)fredpont |
| 700 | 1 | a Aronica, Eleonora4 aut |
| 700 | 1 | a Birnir, Bryndisu Uppsala universitet,Fysiologi4 aut0 (Swepub:uu)brybi979 |
| 710 | 2 | a Uppsala universitetb Neurologi4 org |
| 773 | 0 | t PLOS ONEd : Public Library of Science (PLoS)g 7:5, s. e37041-q 7:5<e37041-x 1932-6203 |
| 856 | 4 | u https://uu.diva-portal.org/smash/get/diva2:530917/FULLTEXT01.pdfx primaryx Raw objecty fulltext:print |
| 856 | 4 | u https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0037041&type=printable |
| 856 | 4 8 | u https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-175309 |
| 856 | 4 8 | u https://doi.org/10.1371/journal.pone.0037041 |
| 856 | 4 8 | u http://kipublications.ki.se/Default.aspx?queryparsed=id:124815072 |
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