id:"swepub:oai:DiVA.org:uu-177460"
Search: id:"swepub:oai:DiVA.org:uu-177460" > Variation in the kl...
- 1 of 1
- Previous record
- Next record
- To hitlist
Variation in the klotho gene is not associated with mortality risk among elderly men in MR OS Sweden
-
- Westerberg, Per-Anton (author)
- Uppsala universitet,Njurmedicin
-
- Kindmark, Andreas (author)
- Uppsala universitet,Metabola bensjukdomar
-
- Linde, Torbjörn (author)
- Uppsala universitet,Njurmedicin
- show more...
- Larsson, T. E. (author)
- Ohlsson, C. (author)
- Tivesten, A. (author)
- Mellstrom, D. (author)
- Karlsson, M. K. (author)
- Westerberg, R-A (author)
- show less...
- (creator_code:org_t)
- Elsevier BV, 2012
- 2012
- English.
- In: Bone. - : Elsevier BV. - 8756-3282 .- 1873-2763. ; 50:Suppl 1, s. S103-S104
- Journal article (other academic/artistic)
Abstract
Subject headings
Close
- Polymorphisms in the Klotho (Kl) gene, which is central for vitamin D regulation by fibroblast growth factor 23 (FGF23), have been associated with longevity, coronary disease and stroke. The CC genotype of the single nucleotide polymorphism (SNP) rs577912 in the Kl-gene is associated with decreased Kl expression, as well as increased mortality in end stage renal disease. We examined if SNP in the Kl-gene was associated with mortality in the community derived cohort of 70 to 80 year old males of MrOS Sweden (N = 3014).High throughput genotyping of the KLOTHO SNPs was achieved by use of SequenomR MassEXTEND/Mass/ARRAY technology. 2738 subjects had a valid result for rs577912: CC 73.1% and CA + AA 26.9%. There were no differences in the serum levels of FGF23, phosphate, parathyroid hormone or renal function between genotypes CC and CA + AA. During a follow-up of a median of 4.5 years there were 337 deaths, 253 (12.6%) in the CC group and 84 (11.4%) in the CA + AA group. With log rank analysis there were no differences in mortality between the genotypes for all cause mortality (P = 0.39) or cardiovascular mortality (P = 0.60). None of the other SNPs in the Kl gene was associated with mortality in this cohort either.Conclusion:There is no association between the SNP rs577912 in the Kl-gene and mortality among elderly men.
Publication and Content Type
- vet (subject category)
- art (subject category)
- 1 of 1
- Previous record
- Next record
- To hitlist
Find more in SwePub
- By the author/editor
- Westerberg, Per- ...
- Kindmark, Andrea ...
- Linde, Torbjörn
- Larsson, T. E.
- Ohlsson, C.
- Tivesten, A.
- show more...
- Mellstrom, D.
- Karlsson, M. K.
- Ljunggren, Östen
- Westerberg, R-A
- show less...
- Articles in the publication
- Bone
- By the university
- Uppsala University
- Karolinska Institutet
Search outside SwePub
- Extend your search to:
- Google Book Search
- Google Scholar
Kungliga biblioteket hanterar dina personuppgifter i enlighet med EU:s dataskyddsförordning (2018), GDPR. Läs mer om hur det funkar här.
Så här hanterar KB dina uppgifter vid användning av denna tjänst.
- Copyright © LIBRIS - National Library Systems
- LIBRIS.kb.se
