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Biomarkers in atrial fibrillation : a clinical review

Hijazi, Ziad (author)
Uppsala universitet,Uppsala kliniska forskningscentrum (UCR),Kardiologi
Oldgren, Jonas (author)
Uppsala universitet,Uppsala kliniska forskningscentrum (UCR),Kardiologi
Siegbahn, Agneta (author)
Uppsala universitet,Uppsala kliniska forskningscentrum (UCR),Klinisk kemi
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Granger, Christopher B (author)
Wallentin, Lars (author)
Uppsala universitet,Uppsala kliniska forskningscentrum (UCR)
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 (creator_code:org_t)
2013-02-05
2013
English.
In: European Heart Journal. - : Oxford University Press (OUP). - 0195-668X .- 1522-9645. ; 34:20, s. 1475-1480
  • Journal article (peer-reviewed)
Abstract Subject headings
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  • Assessment of atrial fibrillation (AF)-associated stroke risk is at present mainly based on clinical risk scores such as CHADS2 and CHA2DS2-VASc, although these scores provide only modest discrimination of risk for individual patients. Biomarkers derived from the blood may help refine risk assessment in AF for stroke outcomes and for mortality. Recent studies of biomarkers in AF have shown that they can substantially improve risk stratification. Cardiac biomarkers, such as troponin and natriuretic peptides, significantly improve risk stratification in addition to current clinical risk stratification models. Similar findings have recently been described for markers of renal function, coagulation, and inflammation in AF populations based on large randomized prospective clinical trials or large community-based cohorts. These new findings may enable development of novel tools to improve clinical risk assessment in AF. Biomarkers in AF may also improve the understanding of the pathophysiology of AF further as well as potentially elucidate novel treatment targets. This review will highlight novel associations of biomarkers and outcomes in AF as well as recent progress in the use of biomarkers for risk stratification.

Subject headings

MEDICIN OCH HÄLSOVETENSKAP  -- Klinisk medicin -- Kardiologi (hsv//swe)
MEDICAL AND HEALTH SCIENCES  -- Clinical Medicine -- Cardiac and Cardiovascular Systems (hsv//eng)

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Hijazi, Ziad
Oldgren, Jonas
Siegbahn, Agneta
Granger, Christo ...
Wallentin, Lars
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MEDICAL AND HEALTH SCIENCES
MEDICAL AND HEAL ...
and Clinical Medicin ...
and Cardiac and Card ...
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European Heart J ...
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Uppsala University

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