International differences in treatment effect: do they really exist and why?

International differences in treatment effect : do they really exist and why?

Pocock, Stuart (author)

Calvo, Gonzalo (author)

Marrugat, Jaume (author)

Prasad, Krishna (author)

Tavazzi, Luigi (author)

Wallentin, Lars (author): Uppsala universitet,Uppsala kliniska forskningscentrum (UCR)

Zannad, Faiez (author)

Alonso Garcia, Angeles (author)

(creator_code:org_t)

2013-03-07
2013
English.
In: European Heart Journal. - : Oxford University Press (OUP). - 0195-668X .- 1522-9645. ; 34:24, s. 1846-1852

Related links:: https://academic.oup...; show more...; https://urn.kb.se/re...; https://doi.org/10.1...; show less...

Abstract Subject headings

With the increasing globalization of clinical trials, the opportunity exists to explore potential geographic differences in treatment effect within any major trial. Such geographic differences may arise because of international differences in patient selection, medical practice, or evaluation of outcomes, and such international variations need better documentation in trial reports. Appropriate pre-defined statistical analyses, including statistical tests of interaction regarding geographic heterogeneity in treatment effect, are important. Geographic variations are a particularly tricky form of subgroup analysis: they lack statistical power, are at best hypothesis-generating and can generate more confusion than insight. Referring to key examples, e.g. the PLATO and MERIT-HF, we emphasize the need for caution in interpreting evidence of potential geographic inconsistencies in treatment effect. Although it is appropriate to explore any biological or practical reasons for apparent geographic anomalies in treatment effect, the play of chance is often the most plausible and wise interpretation.

By the author/editor: Pocock, Stuart; Calvo, Gonzalo; Marrugat, Jaume; Prasad, Krishna; Tavazzi, Luigi; Wallentin, Lars; show more...; Zannad, Faiez; Alonso Garcia, A ...; show less...

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