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Mid-regional pro-atrial natriuretic peptide levels in the elderly : Clinical and prognostic implications, and comparison to B-type natriuretic peptides
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- Eggers, Kai M. (author)
- Uppsala universitet,Kardiologi
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- Venge, Per (author)
- Uppsala universitet,Biokemisk struktur och funktion
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- Lind, Lars (author)
- Uppsala universitet,Kardiologi
- (creator_code:org_t)
- Elsevier BV, 2013
- 2013
- English.
- In: Clinica Chimica Acta. - : Elsevier BV. - 0009-8981 .- 1873-3492. ; 419, s. 62-66
- Journal article (peer-reviewed)
Abstract
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- Background: Mid-regional pro-atrial natriuretic peptide (MR-proANP) is emerging as an indicator of cardiac abnormalities and adverse outcome in heart failure patients. However, there are only sparse data on its clinical value relative to the B-type natriuretic peptides in the general population. Methods: We measured levels of MR-proANP, B-type natriuretic peptide (BNP) and N-terminal proBNP (NT-proBNP) in 999 community-dwelling subjects aged 70 years who were participating in the PIVUS study. Results: The MR-proANP and the B-type natriuretic peptides exhibited similar associations to previous or prevalent cardiovascular disease, and echocardiographic data. In subgroups with confounding conditions (female sex, obesity, renal dysfunction), MR-proANP did not exhibit stronger associations to echocardiographic data than the B-type natriuretic peptides. MR-proANP predicted cardiovascular mortality during 8 years of follow-up (adjusted hazard ratio 2.8 [95% confidence interval 1.3-6.1]) but not all-cause mortality (adjusted hazard ratio 1.6[95% confidence interval 1.0-2.5]). Overall, NT-proBNP provided the strongest predictive value regarding both outcomes. Conclusions: MR-proANP levels in an elderly community population are to a similar extent as the B-type natriuretic peptides related to manifestations of cardiovascular disease and echocardiographic data. MR-proANP also predicts long-term cardiovascular mortality but without being prognostically superior compared to the B-type natriuretic peptides.
Keyword
- MR-proANP
- B-type natriuretic peptides
- General population
- Risk prediction
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- ref (subject category)
- art (subject category)
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