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Potentials of high ...
Potentials of high resolution magnetic resonance imaging versus computed tomography for preoperative local staging of colon cancer
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- Rollven, Erik (author)
- Karolinska Institutet
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- Holm, Torbjorn (author)
- Karolinska Institutet
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- Glimelius, Bengt (author)
- Uppsala universitet,Enheten för onkologi
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Lorinc, Esther (author)
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- Blomqvist, Lennart (author)
- Karolinska Institutet
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(creator_code:org_t)
- 2013-09-01
- 2013
- English.
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In: Acta Radiologica. - : SAGE Publications. - 0284-1851 .- 1600-0455. ; 54:7, s. 722-730
- Related links:
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
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- Background: Preoperative identification of locally advanced colon cancer is of importance in order toproperly plan treatment. Purpose: To study high resolution T2-weighted magnetic resonance imaging (MRI) versus computed tomography (CT) for preoperative staging of colon cancer with surgery and histopathology as reference standard. Material and Methods: Twenty-eight patients with a total of 29 tumors were included. Patients were examined on a 1.5 T MR unit using a phased array body coil. T2 turbo spin-echo high resolution sequences were obtained in a coronal, transverse, and perpendicular plane to the long axis of the colon at the site of the tumor. Contrast-enhanced CT was performed using a protocol for metastasis staging. The examinations were independently evaluated by two gastrointestinal radiologists using criteria adapted to imaging for prediction of T-stage, N-stage, and extramural venous invasion. Based on the T-stage, tumors were divided in to locally advanced (T3cd-T4) and not locally advanced (T1-T3ab). Surgical and histopathological findings served as reference standard. Results: Using MRI, T-stage, N-stage, and extramural venous invasion were correctly predicted for each observer in 90% and 93%, 72% and 69%, and 82% and 78% of cases, respectively. With CT the corresponding results were 79% and 76%, 72% and 72%, 78% and 67%. For MRI inter-observer agreements (Kappa statistics) were 0.79, 0.10, and 0.76. For CT the corresponding results were 0.64, 0.66, and 0.22. Conclusion: Patients with locally advanced colon cancer, defined as tumor stage T3cd-T4, can be identified by both high resolution MRI and CT, even when CT is performed with a metastasis staging protocol. MRI may have an advantage, due to its high soft tissue discrimination, to identify certain prognostic factors such as T-stage and extramural venous invasion.
Keyword
- Colon cancer
- staging
- high resolution MRI
- computed tomography
- histopathology
- neoadjuvant treatment
Publication and Content Type
- ref (subject category)
- art (subject category)
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